Recombinant Human NABP1 Protein

Beta LifeScience SKU/CAT #: BL-4004PS
Recombinant Human NABP1 Protein

Recombinant Human NABP1 Protein

Beta LifeScience SKU/CAT #: BL-4004PS
Catalog No.: BL-4004PS

Product Overview

Tag N/A
Host Species Human
Synonym Nucleic Acid Binding Protein 1, OBFC2A, Sensor OfSingle-Strand DNA Complex Subunit B2, Single-Stranded DNA-Binding Protein 2, SSB2,Oligonucleotide/Oligosaccharide-Binding Fold Containing 2A, NucleicAcid-Binding Protein 1, Oligonucleotide/Oligosaccharide-Binding Fold-ContainingProtein 2A, Sensor Of SsDNA Subunit B2, SOSS-B2, SOSS Complex Subunit B2, hSSB2.
Background Nucleic acid binding protein 1 is a part of the SOSS complex, a multiprotein complexwhich functions downstream of the MRN complex to promote DNA repair and G2/Mcheckpoint. In the SOSS complex,NABP1 acts as a sensor of single-stranded DNA which binds to single-strandedDNA, in particularto polypyrimidines. The SOSS complex links with DNA lesions and affects diverse endpoints in the cellular DNA damage response including cell-cycle checkpointactivation, recombinational repair and maintenance of genomic stability. NABP1 is essential forefficient homologous recombination-dependent repair of double-strand breaks (DSBs) andATM-dependent signaling pathways.
Description NABP1 Human Recombinant expressed in E.Coli is a single, non-glycosylated polypeptide chain containing 227a.a. (1-204 a.a) and having a molecular weight of 24.8kDa.
Source E.coli
AA Sequence MGSSHHHHHH SSGLVPRGSH MGSMNRVNDP LIFIRDIKPG LKNLNVVFIV LEIGRVTKTK DGHEVRSCKVADKTGSITIS VWDEIGGLIQ PGDIIRLTRG YASMWKGCLT LYTGRGGELQ KIGEFCMVYS EVPNFSEPNPDYRGQQNKGA QSEQKNNSMN SNMGTGTFGP VGNGVHTGPE SREHQFSHAG RSNGRGLINP QLQGTASNQT VMTTISNGRD PRRAFKR.
Purity >95.0% as determined by SDS-PAGE.
Endotoxin <1.0 EU per μg by the LAL method.
Formulation NABP1 protein solution (0.5mg/ml) containing 20mMTris-HCl buffer (pH 8.0) 0.2M, NaCl, 50% glycerol and 2mM DTT.
Stability Recombinant protein is stable for 12 months at -70°C
Usage For Research Use Only
Storage Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
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