Recombinant Human/Mouse/Rat Irisin Protein (Fc Tag)

Beta LifeScience SKU/CAT #: BL-0136NP
Recombinant Human/Mouse/Rat Irisin Protein (Fc Tag)

Recombinant Human/Mouse/Rat Irisin Protein (Fc Tag)

Beta LifeScience SKU/CAT #: BL-0136NP
Catalog No.: BL-0136NP

Product Overview

Tag Fc
Host Species Human/Mouse/Rat
Accession Q8NAU1
Synonym Human/Mouse/Rat Irisin Fibronectin type III domain-containing protein 5; Fibronectin type III repeat-containing protein 2; Irisin; FNDC5
Background Fibronectin type III domain-containing protein 5, the precursor of irisin, is a protein that is encoded by the FNDC5 gene.Human Irisin is synthesized as a 212 amino acid (aa) precursor encoding a type 1 transmembrane protein with a 121 aa extracellular domain (ECD), a 21 aa transmembrane domain, and a 39 aa cytoplasmic domain. The ECD of Irisin contains a fibronectin type III domain and multiple glycosylation sites. The ECD is proteolytically cleaved to release the 112 aa soluble Irisin hormone into circulation.Mature human, mouse share 100% sequence identity.Irisin induces expression of peroxisome proliferatoractivated receptor γ coactivator 1alpha (PGC1alpha) and uncoupling protein1(UCP1), mitochondrialassociated metabolic proteins. Irisin induces the transition of white adipose tissue into more metabolically active beige adipose tissue.Irisin also regulates neuronal cell differentiation and neurite outgrowth in the brain and is involved in the differentiation of osteoblasts.
Description Recombinant Human/Mouse/Rat Fibronectin type III domain-containing protein 5 is expressed by our Mammalian expression system and the target gene encoding Asp32-Glu143 is expressed with a Fc tag at the C-terminus.
Source Human Cells
AA Sequence Asp32-Glu143
Purity >95% as determined by reducing SDS-PAGE.
Endotoxin <0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Recombinant Human/Mouse/Rat Irisin Protein was lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution Dissolve the lyophilized protein in distilled water.
Usage For Research Use Only
Storage Human/Mouse/Rat Irisin protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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