Recombinant Human Motilin Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-3402
Recombinant Human Motilin Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-3402
Collections: Other recombinant proteins, Recombinant proteins
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Tag | His |
Host Species | Human |
Accession | AAH69675.1 |
Synonym | MLN, Motilin |
Background | MLN have characteristics between nanostructured lipid carriers (NLC) and multiple emulsions (W/O/W), but without the outer aqueous phase.The anticancer small molecule MLN4924, a Nedd8-activating enzyme (NAE) inhibitor, triggers cell-cycle arrest, apoptosis, and senescence in cancer cells. MLN 944 is a bisintercalating DNA-binding antitumor agent known to be a template inhibitor of transcription.MLN-591 is a monoclonal antibody specific for prostate-specific membrane antigen that is being developed by Cornell University, BZL Biologics, ImmunoGen Inc and Millennium Pharmaceuticals Inc for the potential treatment of prostate cancer. |
Description | A DNA sequence encoding the human MLN (AAH69675.1) (Met1-Lys115) was expressed with a His tag at the C-terminus. |
Source | HEK293 |
Predicted N Terminal | Phe 26 |
AA Sequence | Met1-Lys115 |
Molecular Weight | The recombinant human MLN consists 101 a.a. and predicts a molecular mass of 11.8 kDa. |
Purity | >(21.8 + 71.5)% as determined by SDS-PAGE. |
Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
Bioactivity | Please contact us for detailed information |
Formulation | Lyophilized from sterile PBS, pH 7.4.. |
Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
Usage | For Research Use Only |
Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Target Details
Target Function | Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle. |
Subcellular Location | Secreted. |
Protein Families | Motilin family |
Database References |
Gene Functions References
- Hemodialysis improves upper GI symptoms and gastric slow waves in CKD patients. An increase in ghrelin and a decrease in GLP-1 might be involved in the HD-induced improvement in gastric slow waves. PMID: 28566304
- motilin-induced phase III contractions signal hunger in healthy subjects and that this system is disturbed in morbidly obese patients--{REVIEW} PMID: 26660537
- Motilin stimulates growth hormone secretion and regulates interdigestive migrating contractions and fasting motor patterns in the gastrointestinal tract. [REVIEW] PMID: 22632857
- Motilin may directly influence adipocyte functions by stimulating energy storage. PMID: 21771971
- Ghrelin covaried with motilin in plasma in irritable bowel syndrome (IBS) but not in plasma from healthy subjects. This suggests the two peptides act together in IBS. PMID: 20338210
- Plasma levels of motilin were studied in 16 untreated Celiac disease patients and in an age-matched control group of 18 healthy subjects by radioimmunoassay and by high-performance liquid chromatography (HPLC). PMID: 12732349
- Ghrelin and motilin are cosecreted from a prominent endocrine cell population in the small intestine. PMID: 17595255
- The abnormal excretion of hormonal factors is closely related to gallstone formation PMID: 18234640
- About 35.9% of the patients with a T tube after cholecystectomy and choledochotomy have duodenal-biliary reflux. Most of them have sphincter of Oddi hypomotility and the decreased level of plasma motilin and serum gastrin. PMID: 18609694