Recombinant Human MICA Protein (Fc Tag)

Beta LifeScience SKU/CAT #: BL-0015NP
Recombinant Human MICA Protein (Fc Tag)

Recombinant Human MICA Protein (Fc Tag)

Beta LifeScience SKU/CAT #: BL-0015NP
Catalog No.: BL-0015NP

Product Overview

Tag Fc
Host Species Human
Accession Q29983
Synonym MICA MHC Class I Polypeptide-Related Sequence A; MIC-A; MICA; PERB11.1
Background MHC class I polypeptide-related sequence A, also known as MIC-A, PERB11.1 and MICA, is a single-pass type I membrane protein which belongs to the MHC class I family of MIC subfamily. MICA contains one Ig-like C1-type domain and is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by NK cells, NKT cells, and most of the subtypes of T cells. MICA is the ligand for NK cell activating receptor KLRK1/NKG2D. MICA seems to have no role in antigen presentation. MICA leads to cell lysis by binding to KLRK1.
Description Recombinant Human MHC Class I Polypeptide-Related Sequence A is expressed by our Mammalian expression system and the target gene encoding Ala23-Glu308 is expressed with a Fc tag at the C-terminus.
Source Human Cells
AA Sequence Ala23-Glu308
Purity >95% as determined by reducing SDS-PAGE.
Endotoxin <0.1 ng/µg (1 EU/µg) as determined by LAL test.
Bioactivity Measured by its ability to bind Human N2DL2 in functional ELISA. The ED50 for this effect is less than 5 ug/ml.
Formulation Recombinant Human MICA Protein was lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution Dissolve the lyophilized protein in distilled water.
Usage For Research Use Only
Storage Human MICA protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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