Recombinant Human MEK5 Protein

Beta LifeScience SKU/CAT #: BL-0146SG
Recombinant Human MEK5 Protein

Recombinant Human MEK5 Protein

Beta LifeScience SKU/CAT #: BL-0146SG
Catalog No.: BL-0146SG

Product Overview

Tag GST
Host Species Human
Accession BC008838
Synonym MAP2K5, MAPKK5, MKK5, PRKMK5, SAPKK5; SKK5; HsT17454
Background MEK5 or MAP2K5 (mitogen-activated protein kinase kinase 5) is a dual specificity protein kinase that belongs to the MAP kinase kinase family which specifically interacts with and activates MAPK7/ERK5. MEK5 itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by MEK5 is involved in growth factor stimulated cell proliferation and muscle cell differentiation (1). The rs3743354 polymorphism in the MEK5 promoter may affect the risk of developing colorectal cancer (CRC) (2).
Description Recombinant full-length human MEK5 was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods. This protein is purified with our unique purification methods.
Source Sf9 insect cells
AA Sequence Full Length
Molecular Weight ~77 kDa
Purity For specific purity information on a given lot, see related COA.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Active
Formulation Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.
Stability The recombinant protein is stable for up to 12 months at -70°C
Usage For Research Use Only
Storage Recombinant Human MEK5 Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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