Recombinant Human LSAMP Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-3247
Recombinant Human LSAMP Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-3247
Collections: Other recombinant proteins, Recombinant proteins
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Product Overview
Tag | Fc |
Host Species | Human |
Accession | Q13449 |
Synonym | FLJ34254, FLJ35396, FLJ37216, FLJ54658, IGLON3, LAMP |
Background | The limbic system-associated membrane protein (LAMP) is a cell surface glycoprotein expressed by cortical and subcortical regions of the mammalian CNS that comprise or receive direct projections from limbic system structures. The 64-68-kDa glycoprotein limbic system-associated membrane protein (LsAMP) is expressed on the surface of somata and proximal dendrites of neurons. These areas perform cognitive and autonomic functions, also learning and memory. The functional analysis indicates that LsAMP acts as a selective adhesion molecule, serving as a guidance cue for specific patterns of connectivity, which underlies the normal development of the limbic system. In animal studies there have been found that rats with increased level of anxiety had 1.6-fold higher expression of LsAMP gene in the periaqueductal gray compared to rats with low level of anxiety, indicating a possible role of LsAMP in the regulation of anxiety. |
Description | A DNA sequence encoding the human LSAMP (Q13449) (Met 1-Asn 315), without the pro peptide, was was fused with the Fc region of human IgG1 at the C-terminus. |
Source | HEK293 |
Predicted N Terminal | Val 29 |
AA Sequence | Met 1-Asn 315 |
Molecular Weight | The secreted recombinant human LSAMP/Fc is a disulfide-linked homodimer. Yhe reduced monomer consists of 528 a.a. and has a predicted molecular mass of 59 kDa. As a result of glycosylation, the apparent molecular mass of rhLSAMP/Fc monomer is approximately 80-85 kDa in SDS-PAGE under reducing conditions. |
Purity | >97% as determined by SDS-PAGE |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
Bioactivity | 1. Measured by its binding ability in a functional ELISA.2. Immobilized recombinant human OPCML-His at 10 ug/mL can bind recombinant human LSAMP-Fc with a linear range of 31.25-250 ng/ml. |
Formulation | Lyophilized from sterile PBS, pH 7.4. |
Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
Usage | For Research Use Only |
Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |