Recombinant Human LOXL2 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-3223
Recombinant Human LOXL2 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-3223
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Product Overview
Tag | His |
Host Species | Human |
Accession | Q9Y4K0 |
Synonym | LOR2, Lysyl oxidase-like 2, WS9-14 |
Background | Lysyl oxidase homolog 2, also known as Lysyl oxidase-like protein 2, Lysyl oxidase-related protein 2, Lysyl oxidase-related protein WS9-14 and LOXL2, is a secreted protein which belongs to thelysyl oxidase family. LOXL2 contains fourSRCR domains. The lysyl oxidase family is made up of five members: lysyl oxidase (LOX) and lysyl oxidase-like 1-4 ( LOXL1, LOXL2, LOXL3, LOXL4 ). All members share conserved C-terminal catalytic domains that provide for lysyl oxidase or lysyl oxidase-like enzyme activity; and more divergent propeptide regions. LOX family enzyme activities catalyze the final enzymatic conversion required for the formation of normal biosynthetic collagen and elastin cross-links. LOXL2 is expressed by pre-hypertrophic and hypertrophic chondrocytes in vivo, and that LOXL2 expression is regulated in vitro as a function of chondrocyte differentiation. LOXL2 promotes chondrocyte differentiation by mechanisms that are likely to include roles as both a regulator and an effector of chondrocyte differentiation. LOXL2 expression could also be explored as a molecular target in the prevention of breast cancer progression. |
Description | A DNA sequence encoding the human LOXL2 (Q9Y4K0) (Met1-Gln774) was expressed, fused with a His tag at the C-terminus. |
Source | CHO Stable Cells |
Predicted N Terminal | Gln 26 |
AA Sequence | Met1-Gln774 |
Molecular Weight | The recombinant human LOXL2 consists of 760 a.a. and has a predicted molecular mass of 85.5 kDa. |
Purity | (67+30)% as determined by SDS-PAGE |
Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
Bioactivity | Measured by its ability to produce hydrogen peroxide during the oxidation of benzylamine.The specific activity is >2pmol/min/ug |
Formulation | Lyophilized from sterile 20 mM MES, 50 mM NaCl. |
Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
Usage | For Research Use Only |
Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |