Recombinant Human KIF5B-RET (V804L) Protein

Beta LifeScience SKU/CAT #: BL-0096SG
Recombinant Human KIF5B-RET (V804L) Protein

Recombinant Human KIF5B-RET (V804L) Protein

Beta LifeScience SKU/CAT #: BL-0096SG
Catalog No.: BL-0096SG

Product Overview

Tag GST
Host Species Human
Accession NM_004521NM_020630
Synonym KIF5B: KINH, UKHC, KNSRET: CDHF12, RET51, PTC, RET-ELE1; RET/PTC2
Background RET or ret proto-oncogene is a member of the cadherin superfamily that encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. RET can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement (1). RET signaling pathway, by regulating the development of both the nervous and lymphoid system in the gut, plays a key role in the molecular mechanisms that orchestrate intestine organogenesis (2). The KIF5B-RET fusion was reported to be one of the driver mutations of lung adenocarcinomas and that Vandetanib inhibits the anchorage-independent growth activity induced by the fusion.
Description Recombinant human fusion KIF5B (1- 575 a.a., exons1-15) -RET (V804L) (713 a.a. - end, exons 14-21), was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods.
Source Sf9 insect cells
AA Sequence 713 a.a. - end, exons 14-21
Molecular Weight 132 kDa
Purity For specific purity information on a given lot, see related COA.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Active
Formulation Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.
Stability The recombinant protein is stable for up to 12 months at -70°C
Usage For Research Use Only
Storage Recombinant Human KIF5B-RET (V804L) Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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