Recombinant Human Intestine-Specific Homeobox (ISX) Protein (His-SUMO)
Beta LifeScience
SKU/CAT #: BLC-09806P

Greater than 90% as determined by SDS-PAGE.
Recombinant Human Intestine-Specific Homeobox (ISX) Protein (His-SUMO)
Beta LifeScience
SKU/CAT #: BLC-09806P
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Description | Recombinant Human Intestine-Specific Homeobox (ISX) Protein (His-SUMO) is produced by our E.coli expression system. This is a full length protein. |
Purity | Greater than 90% as determined by SDS-PAGE. |
Uniprotkb | Q2M1V0 |
Target Symbol | ISX |
Synonyms | DKFZp781N2395; Intestine-specific homeobox; Isx; ISX_HUMAN; MGC138417; OTTHUMP00000028558; Pancreas intestine homeodomain transcription factor; Pix 1; RAX like homeobox; RAX-like homeobox; RAXLX |
Species | Homo sapiens (Human) |
Expression System | E.coli |
Tag | N-6His-SUMO |
Target Protein Sequence | MCAEVGPALCRGMERNSLGCCEAPKKLSLSFSIEAILKRPARRSDMDRPEGPGEEGPGEAAASGSGLEKPPKDQPQEGRKSKRRVRTTFTTEQLHELEKIFHFTHYPDVHIRSQLAARINLPEARVQIWFQNQRAKWRKQEKIGNLGAPQQLSEASVALPTNLDVAGPTWTSTALRRLAPPTSCCPSAQDQLASAWFPAWITLLPAHPWETQPVPGLPIHQTCIPVLCILPPPHPKWGSICATST |
Expression Range | 1-245aa |
Protein Length | Full Length |
Mol. Weight | 43.0kDa |
Research Area | Epigenetics And Nuclear Signaling |
Form | Liquid or Lyophilized powder |
Buffer | Liquid form: default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
Reconstitution | Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
Storage | 1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
Target Details
Target Function | Transcription factor that regulates gene expression in intestine. May participate in vitamin A metabolism most likely by regulating BCO1 expression in the intestine. |
Subcellular Location | Nucleus. |
Database References |
Gene Functions References
- our results indicate that E2F1 is an important downstream gene of ISX in hepatoma progression. PMID: 27175585
- Results show that ISX expression mediated AHR-induced tumorigenesis in hepatocellular carcinoma. PMID: 28398627
- Overall, our results identified a feed-forward mechanism of immune suppression in hepatocellular carcinoma organized by ISX, which involves kynurenine-AHR signaling and PD-L1, offering insights into immune escape by hepatocellular carcinoma PMID: 28625979
- ISX expression induced by H. pylori infection may lead to intestinal metaplasia and hyperproliferation of gastric mucosa through CDX1/2 and cyclinD1 expression, contributing to gastric carcinogenesis. PMID: 26872890
- Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX PMID: 23393141
- our results highlight ISX as an important regulator in hepatoma progression with significant potential as a prognostic and therapeutic target in HCCs. PMID: 23221382