Recombinant Human Interleukin-19 Protein (IL19), Active

Beta LifeScience SKU/CAT #: BLC-05390P

Recombinant Human Interleukin-19 Protein (IL19), Active

Beta LifeScience SKU/CAT #: BLC-05390P
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Product Overview

Description Recombinant Human Interleukin-19 Protein (IL19), Active is produced by our E.coli expression system. This is a protein fragment.
Purity Greater than 95% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Activity Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human IL-20Rα and human IL-20Rβ co-transfected murine BaF3 pro-B cells is less than 1.5 ng/ml, corresponding to a specific activity of >6.7x10 5 IU/mg.
Uniprotkb Q9UHD0
Target Symbol IL19
Synonyms IL 10C; IL 19; IL-19; Il19; IL19_HUMAN; Interleukin 19; Interleukin-19; MDA1; Melanoma differentiation-associated protein-like protein; NG.1; ZMDA1
Species Homo sapiens (Human)
Expression System E.coli
Tag Tag-Free
Complete Sequence LRRCLISTDM HHIEESFQEI KRAIQAKDTF PNVTILSTLE TLQIIKPLDV CCVTKNLLAF YVDRVFKDHQ EPNPKILRKI SSIANSFLYM QKTLRQCQEQ RQCHCRQEAT NATRVIHDNY DQLEVHAAAI KSLGELDVFL AWINKNHEVM SSA
Expression Range 25-177aa
Protein Length Partial of AF192498
Mol. Weight 17.9 kDa
Research Area Immunology
Form Lyophilized powder
Buffer Lyophilized from a 0.2 µm filtered PBS, pH 7.4
Reconstitution Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%.
Storage 1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target Function May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis.
Subcellular Location Secreted.
Protein Families IL-10 family
Database References

HGNC: 5990

OMIM: 605687

KEGG: hsa:29949

STRING: 9606.ENSP00000343000

UniGene: PMID: 28597022

  • IL-19 is significantly positive correlated with UAE and Cystatin C. IL-19 may play an important role that contributes to the progression of diabetic nephropathy. PMID: 28201997
  • The authors identified highly significant associations with better melanoma overall survival for rs6673928, impacting IL19 expression (HR, 0.56; 95% CI, 0.41-0.77; P = 0.0002) and rs6695772, controlling the expression of BATF3 (HR, 1.64; 95% CI, 1.19-2.24; P = 0.0019). PMID: 26733611
  • a set of IL-17A-regulated genes in keratinocytes, which recapitulate typical psoriasis genes exemplified by DEFB4A, S100A7, IL19 and CSF3, based on the differences in the expression profiles of cells stimulated with six cytokines versus cells stimulated with only five cytokines lacking IL-17A. PMID: 26944069
  • findings show that the expression of IL19 in biopsies of patients with active ulcerative colitis was increased compared with patients with quiescent ulcerative colitis; microbial-driven expression of IL-19 by intestinal macrophages may contribute to the pathogenesis of inflammatory bowel disease PMID: 28864472
  • The SNP of IL-19 rs1798 may be associated with susceptibility to hepatitis B in children. PMID: 27974122
  • The frequency of allele C in rs2243188 was lower in the SLE population. PMID: 27173295
  • These data are the first to implicate the association between the interleukin-19 and type 2 diabetes mellitus with vascular complications. PMID: 27182008
  • IL-19 and Ang-2 might be involved in angiogenesis of T2 Diabetes mellitus complications. PMID: 26657726
  • Data show reduced cytokines IL-10 and IL-19 expression, and enhanced IL-20 and il-1 beta expression in chronic recurrent multifocal osteomyelitis (CRMO) monocytes. PMID: 26404542
  • The level of IL-19 in the peripheral blood of allergic rhinitis(AR) patients increased and was related with the clinical severity of AR. PMID: 26522365
  • these findings suggest that molecular features at the IL19 locus may modestly alter the establishment of HIV-1 infection. PMID: 25633979
  • IL-19 rs2243188 SNP was associated with the susceptibility to lupus nephritis in a Chinese population; but the minor C allele of SNP rs2243188 might be a protective factor for systemic lupus erythematosus PMID: 24819332
  • These findings indicate that IL-19 production is diminished in SpA. Taken together, impaired IL-19 control of the innate immune system might be involved in the pathogenesis of SpA. PMID: 25639337
  • Unstimulated and TLR-activated monocytes expressed significantly lower IL-19 mRNA in active CD patients.Exogenous IL-19 had an anti-inflammatory effect on HC but not in CD. PMID: 24718601
  • IL-19 as a component of the IL-23/IL-17 axis strengthens the IL-17A action and might be a biomarker for the activity of this axis in chronic inflammatory disorders PMID: 25046339
  • we delineate the detailed molecular pathway for IL-4 up-regulation of IL-19 in keratinocytes, which may play an important role in AD pathogenesis. PMID: 24943510
  • results suggest that the IL-19 gene might slightly contribute to the genetic risk of schizophrenia. PMID: 24361379
  • It supresses inflammation and its gene deletion causes inflammatory bowel disease.(review) PMID: 24919552
  • IL-19 is important for cutaneous wound healing because it upregulates KGF expression. PMID: 23582717
  • In breast cancer, IL-19 expression is correlated with increased mitotic figures, advanced tumor stage, higher metastasis, and poor survival. (Review) PMID: 23710200
  • IL-19 does not reduce TNF-alpha-stimulated NF-kappaB activation in Vascular endothelial cells but does decrease serine phosphorylation and cytoplasmic translocation of the mRNA stability factor HuR and significantly reduces stability of ICAM-1 and VCAM-1 mRNA. PMID: 23596173
  • A significant association was found between the combined genotypes of IL19GC + CC and IL20TG + GG and increased risk of vesicoureteral reflux. PMID: 23000500
  • subset of fetuses with fetal inflammatory response syndrome had high umbilical cord plasma IL-19 concentrations PMID: 21767236
  • IL-19 is overexpressed in the epithelium in Chronic rhinosinusitis with nasal polyps and increases epithelial cell proliferation. PMID: 22583192
  • Methylation in IL-19 is associated with Crohn's disease. PMID: 22021194
  • IL-19 is pivotal in the pathogenesis of breast cancer. PMID: 22186257
  • Interleukin-19 (IL-19) induces heme oxygenase-1 (HO-1) expression and decreases reactive oxygen species in human vascular smooth muscle cells. PMID: 22158875
  • protective role of gene polymorphisms in Mexican patients with ulcerative colitis PMID: 21925224
  • Genetic variation in adaptive immunity genes and particularly in IL19/IL20 genes associates with the development of recurrent wheeze after respiratory syncytial virus lower respiratory tract infection. PMID: 21814157
  • The minor allele of the IL19 rs2243188 single nucleotide polymorphism was significantly increased in vitiligo patients compared to controls. PMID: 20699607
  • IL-19 is mitogenic and chemotactic for endothelial cells and can induce their angiogenic potential. PMID: 20966397
  • Analysis of the IL-19 promoter region shows a fragment of 394 base pairs that supports luciferase activity at a level 7- to 8-fold greater than that of the negative control. PMID: 12370360
  • an examination of the helical crystal structure of this protein PMID: 12403790
  • forms stable complex with interleukin-20 receptor PMID: 14580208
  • IL-19 and IL-20 are synthesized by a distinct population of keratinocytes PMID: 14675174
  • Elevated IL-19 serum levels in asthmatic patients are positively correlated with levels of IL-4 and IL-13, and suggest that IL-19 may play a role in the pathogenesis of asthma. PMID: 15557163
  • We identified the sequence TGTGGT (-142 to -138) on PE1 as the binding site for the transcription factor AML1, and crucial for the promoter activity of IL-19 because substituting 1bp in the PE region (-139G-->T) abolished IL-19 promoter activity. PMID: 16631120
  • Data indicate that adenosine increases the release of IL-19 from bronchial epithelial cells via activation of adenosine A(2B) receptors, and IL-19 in turn activates human monocytes to release TNF-alpha, which upregulates A(2B) receptor expression. PMID: 16778150
  • study supports the hypothesis that variations of genes of the IL-19 subfamily of cytokines influence susceptibility to palmoplantar pustulosis PMID: 17263806
  • IL-19 expression in uraemic patients has a role in the Th2 immune responses and may have a role in the cytokine dysregulation in uraemia PMID: 17449492
  • Review. The role of IL-19 in the pathogenesis of inflammatory diseases is reviewed. PMID: 17465720
  • data suggest that IL-19 polymorphisms may be associated with age in a Japanese population PMID: 17522354
  • serum levels of IL-19 were higher in endotoxic shock patients than in healthy volunteers PMID: 18246602
  • IL-19 expression in vascular smooth muscle cells (VSMCs) may represent a novel, protective, autocrine response of VSMCs to inflammatory stimuli. PMID: 18669613
  • IL-19 was positively stained in 15 healthy tissue types & 3 major cell types: epithelial cells, endothelial cells & macrophages; several types of tumor cells stained for IL-19, especially squamous cell carcinoma of skin, tongue, esophagus & lung PMID: 18809337
  • A study of 54 SNPs and haplotypes in the IL10 region indicate that IL10 and IL19/IL20 may be involved in natural clearance of HCV in the African Americans while no significant associations were detected in European Americans. PMID: 15815689
  • IL-19 upregulates IL-4 expression and the number of IL-4 expressing CD4+ve T-cells PMID: 15120647
  • IL-19 induces IL-10, which in turn down-regulates IL-19. PMID: 15827959

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    Proteins are sensitive to heat, and freeze-drying can preserve the activity of the majority of proteins. It improves protein stability, extends storage time, and reduces shipping costs. However, freeze-drying can also lead to the loss of the active portion of the protein and cause aggregation and denaturation issues. Nonetheless, these adverse effects can be minimized by incorporating protective agents such as stabilizers, additives, and excipients, and by carefully controlling various lyophilization conditions.

    Commonly used protectant include saccharides, polyols, polymers, surfactants, some proteins and amino acids etc. We usually add 8% (mass ratio by volume) of trehalose and mannitol as lyoprotectant. Trehalose can significantly prevent the alter of the protein secondary structure, the extension and aggregation of proteins during freeze-drying process; mannitol is also a universal applied protectant and fillers, which can reduce the aggregation of certain proteins after lyophilization.

    Our protein products do not contain carrier protein or other additives (such as bovine serum albumin (BSA), human serum albumin (HSA) and sucrose, etc., and when lyophilized with the solution with the lowest salt content, they often cannot form A white grid structure, but a small amount of protein is deposited in the tube during the freeze-drying process, forming a thin or invisible transparent protein layer.

    Reminder: Before opening the tube cap, we recommend that you quickly centrifuge for 20-30 seconds in a small centrifuge, so that the protein attached to the tube cap or the tube wall can be aggregated at the bottom of the tube. Our quality control procedures ensure that each tube contains the correct amount of protein, and although sometimes you can't see the protein powder, the amount of protein in the tube is still very precise.

    To learn more about how to properly dissolve the lyophilized recombinant protein, please visit Lyophilization FAQs.

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