Recombinant Human IkBA Protein
Beta LifeScience
SKU/CAT #: BL-1038SG
Recombinant Human IkBA Protein
Beta LifeScience
SKU/CAT #: BL-1038SG
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Tag | GST |
Host Species | Human |
Accession | NM_020529 |
Synonym | NFKBIA, MAD-3, NFKBI |
Background | IκBalpha is an inhibitor of the NFκB complex and inactivates the NFκB by trapping it in the cytoplasm (1). Phosphorylation of serine residues on the IκB protein by IκB kinases (IKKs) marks it for destruction via the ubiquitination pathway, thereby allowing the activation of the NFκB complex. Synthetic glucocorticoid such as dexamethasone display anti-inflammatory effects by inducing the increased synthesis of the IκB protein thereby inhibiting the activity of the NFκB complex. Overexpression of the IκBalpha gene in fibroblasts leads to inhibition of production of IL-6, TNF receptor, MMP-1, MMP-3 and MMP-13 (2). |
Description | Recombinant human IkBA (1-175) was produced in E. coli system, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods. |
Source | E.coli |
AA Sequence | 1-175a.a. |
Molecular Weight | ~46 kDa |
Purity | For specific purity information on a given lot, see related COA. |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
Formulation | Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol. |
Stability | The recombinant protein is stable for up to 12 months at -70°C |
Usage | For Research Use Only |
Storage | Recombinant Human IkBA Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |