Recombinant Human IgJ Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-2607
Recombinant Human IgJ Protein (His Tag)

Recombinant Human IgJ Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-2607
Catalog No.: BLPSN-2607

Product Overview

Tag His
Host Species Human
Accession NP_653247.1
Synonym IGCJ, JCH
Background Immunoglobulin J chain, also known as IGJ and IGCJ, is a secreted polypeptide which is the first immunoglobulin-related polypeptide expressed during the embryogenesis and differentiation of B cells in the fetal liver. The joining Immunoglobulin J chain is a small polypeptide, expressed by mucosal and glandular plasma cells, which regulates polymer formation of immunoglobulin (Ig)A and IgM. Immunoglobulin J chain / IGJ serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. Immunoglobulin J chain / IGJ also help to bind these immunoglobulins to secretory component. J-chain incorporation into polymeric IgA (pIgA, mainly dimers) and pentameric IgM endows these antibodies with several salient features. Immunoglobulin J chain / IGJ is involved in creating the binding site for pIgR / SC in the Ig polymers, not only by determining the polymeric quaternary structure but apparently also by interacting directly with the receptor protein. Both the immunoglobulin J chain / IGJ and the pIgR/SC are key proteins in secretory immunity.
Description A DNA sequence encoding the mature form of human IGJ (NP_653247.1) (Gln 23-Asp 159) was fused with a His tag at the C-terminus and a pelB singnal peptide at the N-terminus.
Source E.coli
Predicted N Terminal Gln 23
AA Sequence Gln 23-Asp 159
Molecular Weight The recombinant human IGJ comprises 147 a.a. and has a predicted molecular mass of 17 kDa. It migrates as an approximately 26 kDa band in SDS-PAGE under reducing conditions.
Purity >90% as determined by SDS-PAGE
Endotoxin Please contact us for more information.
Bioactivity Please contact us for detailed information
Formulation Lyophilized from sterile PBS, pH 8.0.
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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