Recombinant Human IFNAR1 Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2538
Recombinant Human IFNAR1 Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2538
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Tag | Fc |
Host Species | Human |
Accession | P17181 |
Synonym | AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC |
Background | Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1, in which Tyr466 is changed to phenylalanine, can act in a dominant negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors. |
Description | A DNA sequence encoding the human IFNAR1 isoform 1 (P17181-1) extracellular domain (Met 1-Lys 436) was fused with the Fc region of human IgG1 at the C-terminus. |
Source | HEK293 |
Predicted N Terminal | Lys 28 |
AA Sequence | Met 1-Lys 436 |
Molecular Weight | The recombinant human IFNAR1/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 650 a.a. and has a predicted molecular mass of 74 kDa. The apparent molecular mass of the reduced monomer is approximately 100-120 kDa in SDS-PAGE under reducing conditions due to glycosylation. |
Purity | >88% as determined by SDS-PAGE |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
Bioactivity | Please contact us for detailed information |
Formulation | Lyophilized from sterile PBS, pH 7.4. |
Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
Usage | For Research Use Only |
Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |