Recombinant Human HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Tetramer Protein
Beta LifeScience
SKU/CAT #: BLK-01658P-100UG

Human HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Tetramer on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Recombinant Human HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Tetramer Protein
Beta LifeScience
SKU/CAT #: BLK-01658P-100UG
Collections: Fc receptors, High-quality recombinant proteins
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Description | Recombinant Human HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Tetramer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus, tetramer is assembled by biotinylated monomer and streptavidin. It contains Gly25-Thr305(HLA-A*02:01),Ile21-Met119(B2M) and HMTEVVRRC peptide. |
Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
Accession | A0A140T913(HLA-A*02:01)&P61769(B2M)&HMTEVVRRC |
Target Symbol | P53 (HLA-A*02:01) Tetramer |
Synonyms | MHC; HLA-A; P53; TP53; Antigen NY-CO-13; BCC7; FLJ92943; LFS1; TRP53 |
Species | Human |
Expression System | HEK293 |
Tag | C-His-Avi |
Expression Range | Gly25-Thr305(HLA-A*02:01),Ile21-Met119(B2M)and HMTEVVRRC peptide |
Mol. Weight | The protein has a predicted MW of 258 kDa. Due to glycosylation, the protein migrates to 260-265 kDa under Non reducing (N) condition based on Tris-Bis PAGE result. |
Form | Lyophilized |
Formulation | Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Endotoxin | Less than 1EU per ug by the LAL method. |
Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
Shipping | Shipped at ambient temperature. |
Gene Background | p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein. p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth. |