Name: Recombinant Human HDAC3 (NCOR2) Protein
Brand: Beta LifeScience
SKU: BL-0219SG
Availability: InStock

Catalog No.: BL-0219SG

Product Overview

Tag	GST-
Host Species	Human
Accession	NM_003883NM_006312
Synonym	HDAC3: HD3; RPD3; RPD3-2 / NCOR2: CTG26; N-CoR2; SMAP270; SMRT; SMRTE; SMRTE-tau; TNRC14; TRAC; TRAC1
Background	HDAC3 or Histone deacetylase 3 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex that represses transcription when tethered to a promoter. HDAC3 may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. HDAC3 can also down-regulate p53 function and thus modulate cell growth and apoptosis. Catalytic domain of HDAC4 can interact with HDAC3 via the transcriptional corepressor NCOR2 (1). RELA is a nonhistone substrate of HDAC3 and IKBA-dependent nuclear export of the HDAC3-deacetylated RELA replenishes the depleted cytoplasmic pool of latent NFKB-IKBA complexes (2).
Description	Human recombinant HDAC3 (full-length)/NCOR2 (237-489) complex was produced by baculovirus in Sf9 insect cells using a C-terminal GST-tag for HDAC3 and N-terminual GST-tag for NCOR2.
Source	Sf9 insect cells
AA Sequence	Full Length
Molecular Weight	HDAC3 ~83 kDa and NCOR2 ~60 kDa
Purity	For specific purity information on a given lot, see related COA.
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity	Active
Formulation	Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.
Stability	The recombinant protein is stable for up to 12 months at -70°C
Usage	For Research Use Only
Storage	Recombinant Human HDAC3 (NCOR2) Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.