Recombinant Human GRK3 Protein

Beta LifeScience SKU/CAT #: BL-0330SG
Recombinant Human GRK3 Protein

Recombinant Human GRK3 Protein

Beta LifeScience SKU/CAT #: BL-0330SG
Catalog No.: BL-0330SG

Product Overview

Tag GST
Host Species Human
Accession NM_005160
Synonym ADRBK2; BARK2
Background GRK3 or beta-adrenergic receptor kinase 2 specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. GRK3 is a member of the receptor kinase family that broadly serves to regulate receptor function (1). GRK3 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. GRK3 is highly expressed in lung, heart, and adipose tissue (2). Single nucleotide polymorphisms (SNPs) in the promoter region of GRK3 have been associated with bipolar disorder.
Description Recombinant human GRK3 (1-554) was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods.
Source Sf9 insect cells
AA Sequence 1-554
Molecular Weight ~84 kDa
Purity For specific purity information on a given lot, see related COA.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Active
Formulation Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.
Stability The recombinant protein is stable for up to 12 months at -70°C
Usage For Research Use Only
Storage Recombinant Human GRK3 Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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