Recombinant Human GRK3 Protein
Beta LifeScience
SKU/CAT #: BL-0330SG
Recombinant Human GRK3 Protein
Beta LifeScience
SKU/CAT #: BL-0330SG
Catalog No.: BL-0330SG
Product Overview
| Tag | GST |
| Host Species | Human |
| Accession | NM_005160 |
| Synonym | ADRBK2; BARK2 |
| Background | GRK3 or beta-adrenergic receptor kinase 2 specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. GRK3 is a member of the receptor kinase family that broadly serves to regulate receptor function (1). GRK3 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. GRK3 is highly expressed in lung, heart, and adipose tissue (2). Single nucleotide polymorphisms (SNPs) in the promoter region of GRK3 have been associated with bipolar disorder. |
| Description | Recombinant human GRK3 (1-554) was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods. |
| Source | Sf9 insect cells |
| AA Sequence | 1-554 |
| Molecular Weight | ~84 kDa |
| Purity | For specific purity information on a given lot, see related COA. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Bioactivity | Active |
| Formulation | Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol. |
| Stability | The recombinant protein is stable for up to 12 months at -70°C |
| Usage | For Research Use Only |
| Storage | Recombinant Human GRK3 Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
