Recombinant Human gp130 Protein (ECD, Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2300
Recombinant Human gp130 Protein (ECD, Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2300
Catalog No.: BLPSN-2300
Product Overview
| Tag | Fc |
| Host Species | Human |
| Accession | AAA59155.1 |
| Synonym | CD130, CDW130, GP130, IL-6RB |
| Background | Glycoprotein 13 (also known as gp13, IL6ST, IL6-beta or CD13) is a transmembrane protein which is the founding member of the class of all cytokine receptors. CD13/gp13 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD13/gp13 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD13/gp13 plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp13 for initiating signal transmission. CD13/gp13 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD13/gp13 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events. |
| Description | A DNA sequence encoding the human IL6ST (AAA59155.1) (Met1-Ile618) was expressed with the Fc region of human IgG1 at the C-terminus. |
| Source | HEK293 |
| Predicted N Terminal | Glu 23 |
| AA Sequence | Met1-Ile618 |
| Molecular Weight | The recombinant human IL6ST consists 834 a.a. and predicts a molecular mass of 94.4 kDa. |
| Purity | >90% as determined by SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4.. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
