Name: Recombinant Human gp130 Protein
Brand: Beta LifeScience
SKU: BLPSN-2299
Availability: InStock

Catalog No.: BLPSN-2299

Product Overview

Tag	N/A
Host Species	Human
Accession	NP_002175.2
Synonym	CD130, CDW130, GP130, IL-6RB
Background	Glycoprotein 13 (also known as gp13, IL6ST, IL6-beta or CD13) is a transmembrane protein which is the founding member of the class of all cytokine receptors. CD13/gp13 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD13/gp13 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD13/gp13 plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp13 for initiating signal transmission. CD13/gp13 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD13/gp13 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events.
Description	A DNA sequence encoding the human IL6RB (NP_002175.2)(Met1-Ile618) was expressed with six amino acids (ENLYFQ) at the C-terminus.
Source	HEK293
Predicted N Terminal	Glu 23
AA Sequence	Met1-Ile618
Molecular Weight	The recombinant human IL6RB consists of 603 a.a. and predicts a molecular mass of 68.6 KDa. It migrates as an approximately 69-99 KDa band in SDS-PAGE under reducing conditions due to glycosylation.
Purity	>90% as determined by SDS-PAGE
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity	Please contact us for detailed information
Formulation	Lyophilized from sterile PBS, pH 7.4..
Stability	The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage	For Research Use Only
Storage	Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.