Recombinant Human GLTPD1 Protein

Name: Recombinant Human GLTPD1 Protein
Brand: Beta LifeScience
SKU: BL-3848PS
Availability: InStock

Collections: Other recombinant proteins, Recombinant proteins

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Product Overview

Tag	N/A
Host Species	Human
Synonym	Ceramide-1-Phosphate Transfer Protein, GlycolipidTransfer Protein Domain-Containing Protein 1, Glycolipid Transfer ProteinDomain Containing 1, GLTP Domain-Containing Protein 1, GLTPD1, GLTPD1, Ceramide-1-phosphatetransfer protein, CPTP.
Background	Glycolipid Transfer Protein Domain Containing 1 (GLTPD1) belongs to theGLTP family. GLTPD1 mediates the intracellular transfer of ceramide-1-phosphatebetween organelle membranes and the cell membrane. GLTPD1 is essential fornormal structure of the Golgi stacks. In addition, GLTPD1 is able to bindphosphoceramides with a diversity of aliphatic chains, however GLTPD1 has apreference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains.Moreover, GLTPD1 is inefficient with phosphoceramides which contains lignoceryl(C24:0). GLTPD1 participates in the regulation of the cellular levels ofceramide-1-phosphate, and in that way contributes to the regulation ofphospholipase PLA2G4A activity and the release of arachidonic acid.
Description	GLTPD1 Human Recombinant expressed in E.Coli is a single,non-glycosylated polypeptide chain containing 237a.a. (1-214 a.a) andhaving a molecular weight of 26.8kDa.
Source	E.coli
AA Sequence	MGSSHHHHHH SSGLVPRGSH MGSMDDSETG FNLKVVLVSF KQCLDEKEEV LLDPYIASWK GLVRFLNSLGTIFSFISKDV VSKLRIMERL RGGPQSEHYR SLQAMVAHEL SNRLVDLERR SHHPESGCRT VLRLHRALHWLQLFLEGLRT SPEDARTSAL CADSYNASLA AYHPWVVRRAVTVAFCTLPT REVFLEAMNV GPPEQAVQML GEALPFIQRV YNVSQKLYAEHSLLDLP.
Purity	>90.0% as determined by SDS-PAGE.
Endotoxin	<1.0 EU per μg by the LAL method.
Formulation	GLTPD1 protein solution (0.25mg/ml) containing Phosphatebuffered saline (pH7.4), 50% glycerol and 1mM DTT.
Stability	Recombinant protein is stable for 12 months at -70°C
Usage	For Research Use Only
Storage	Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.

FAQs

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Proteins are sensitive to heat, and freeze-drying can preserve the activity of the majority of proteins. It improves protein stability, extends storage time, and reduces shipping costs. However, freeze-drying can also lead to the loss of the active portion of the protein and cause aggregation and denaturation issues. Nonetheless, these adverse effects can be minimized by incorporating protective agents such as stabilizers, additives, and excipients, and by carefully controlling various lyophilization conditions.

Commonly used protectant include saccharides, polyols, polymers, surfactants, some proteins and amino acids etc. We usually add 8% (mass ratio by volume) of trehalose and mannitol as lyoprotectant. Trehalose can significantly prevent the alter of the protein secondary structure, the extension and aggregation of proteins during freeze-drying process; mannitol is also a universal applied protectant and fillers, which can reduce the aggregation of certain proteins after lyophilization.

Our protein products do not contain carrier protein or other additives (such as bovine serum albumin (BSA), human serum albumin (HSA) and sucrose, etc., and when lyophilized with the solution with the lowest salt content, they often cannot form A white grid structure, but a small amount of protein is deposited in the tube during the freeze-drying process, forming a thin or invisible transparent protein layer.

Reminder: Before opening the tube cap, we recommend that you quickly centrifuge for 20-30 seconds in a small centrifuge, so that the protein attached to the tube cap or the tube wall can be aggregated at the bottom of the tube. Our quality control procedures ensure that each tube contains the correct amount of protein, and although sometimes you can't see the protein powder, the amount of protein in the tube is still very precise.

To learn more about how to properly dissolve the lyophilized recombinant protein, please visit Lyophilization FAQs.