Recombinant Human GLK Protein

Beta LifeScience SKU/CAT #: BL-0294SG
Recombinant Human GLK Protein

Recombinant Human GLK Protein

Beta LifeScience SKU/CAT #: BL-0294SG
Catalog No.: BL-0294SG

Product Overview

Tag GST
Host Species Human
Accession NM_003618
Synonym MAP4K3; MAPKKKK3; MEKKK3; RAB8IPL1
Background GLK is a member of the STE20 family of serine/threonine protein kinases and contains N-terminal catalytic domain and C-terminal regulatory domain. GLK is upstream of the MEKK1 target and is stimulated by UV radiation and TNF- and can lead to the activation of the JNK signaling pathway. GLK can directly activate PKC-θ¸ during TCR signaling and people with systemic lupus erythematosus show considerable enhanced GLK expression and activation of PKC-θ¸ and the kinase IKK in T cells (1). GLK can act as a pro-apoptotic kinase which orchestrates activation of BAX via the concerted posttranscriptional modulation of PUMA, BAD, and BIM (2).
Description Recombinant human GLK (1-380) was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods.
Source Sf9 insect cells
AA Sequence 1-380
Molecular Weight ~70 kDa
Purity For specific purity information on a given lot, see related COA.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Active
Formulation Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.
Stability The recombinant protein is stable for up to 12 months at -70°C
Usage For Research Use Only
Storage Recombinant Human GLK Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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