Recombinant Human GBA/glucocerebrosidase Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2206
Recombinant Human GBA/glucocerebrosidase Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2206
Catalog No.: BLPSN-2206
Product Overview
| Tag | His |
| Host Species | Human |
| Accession | NP_000148.2 |
| Synonym | GBA1, GCB, GLUC |
| Background | Mutations in the GBA gene, encoding the lysosomal hydrolase glucocerebrosidase (GCase), are the most common known genetic risk factor for Parkinson's disease (PD) and dementia with Lewy bodies (DLB). ASAH1 (acid ceramidase 1) and GBA2 (glucocerebrosidase 2) enzymes that mediate glucosylsphingosine production and metabolism are attractive therapeutic targets for treating mutant GBA-associated PD. |
| Description | A DNA sequence encoding the human GBA (NP_000148.2) (Ala40-Gln536) was expressed with a His tag at the C-terminus. |
| Source | HEK293 |
| Predicted N Terminal | Ala |
| AA Sequence | Ala40-Gln536 |
| Molecular Weight | The recombinant human GBA consists of 508 a.a. and predicts a molecular mass of 57 kDa. |
| Purity | >95% as determined by SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4.. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
