Recombinant Human GADD45G Protein
Beta LifeScience
SKU/CAT #: BLPSN-2181
Recombinant Human GADD45G Protein
Beta LifeScience
SKU/CAT #: BLPSN-2181
Catalog No.: BLPSN-2181
Product Overview
| Tag | N/A |
| Host Species | Human |
| Accession | O95257 |
| Synonym | CR6, DDIT2, GADD45gamma, GRP17 |
| Background | GADD45G, also known as CR6, is part of the nuclear proteins to interact with various proteins whose transcript levels are raised after stressful growth arrest conditions and treatment with DNA-damaging agents. GADD45G reacts to environmental stresses by mediating activation of the p38/JNK pathway which is mediated through their protein binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. GADD45G acts as a new-age tumor suppressor however is being frequently inactivated epigenetically in multiple tumors. GADD45G mRNA expression is down-regulated in hepatocellular carcinoma. GADD45G causes cell cycle arrest at G2/M transition when transfected into Hep-G2 cells. GADD45G induction by androgens involves new protein synthesis. Overexpression of GADD45G inhibits cell growth and causes morphological modifications in prostate cell lines thus GADD45G takes part in differentiation induction by androgens. |
| Description | A DNA sequence encoding human GADD45G (O95257) (Met1-Glu159) was expressed. |
| Source | E.coli |
| Predicted N Terminal | Met |
| AA Sequence | Met1-Glu159 |
| Molecular Weight | The recombinant human GADD45G consists of 159 a.a. and predicts a molecular mass of 17.1 KDa. It migrates as an approximately 17 KDa band in SDS-PAGE under reducing conditions. |
| Purity | >95% as determined by SDS-PAGE |
| Endotoxin | Please contact us for more information. |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4.. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
