Recombinant Human Follistatin Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2121
Recombinant Human Follistatin Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-2121
Collections: Other recombinant proteins, Recombinant proteins
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Tag | His |
Host Species | Human |
Accession | NP_037541.1 |
Synonym | FS |
Background | Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 15 families, evidence was found for linkage between PCOS and follistatin. follistatin are expressed and subserve local regulatory roles in numerous extragonadal tissues, including brain, adrenal, bone marrow, and placenta but perhaps most notably in anterior pituitary-the classical target tissue for inhibin, the activin-follistatin system may play a key role in early embryogenesis. Follistatin binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone follistatin is a binding protein to activin. Since activin binds to follistatin, it is imperative to determine the nature of the activin/follistatin binding complex. |
Description | A DNA sequence encoding the human FST (NP_037541.1) (Met1-Asp329) was expressed with a His tag at the C-terminus. |
Source | HEK293 |
Predicted N Terminal | Gly 30 |
AA Sequence | Met1-Asp329 |
Molecular Weight | The recombinant human FST consists 311 a.a. and predicts a molecular mass of 34.4 kDa. |
Purity | >85% as determined by SDS-PAGE. |
Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
Bioactivity | Measured- by- its- ability- to- neutralize- Activin-mediated- inhibition on MPC11 cell proliferation.The ED50 for this effect is typically 5-40ng/mL. |
Formulation | Lyophilized from sterile PBS, pH 7.4.. |
Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
Usage | For Research Use Only |
Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |