Recombinant Human FGF-10 Protein, Active, Low Endotoxin

Beta LifeScience SKU/CAT #: BEP-0037UL
Recombinant Human FGF-10 (2 ug/lane) on SDS-PAGE under reducing (R) conditions. The gel was stained using Coomassie® Blue showing a single band at 20 kDa and purity greater than 95%. Note: Coomassie Blue staining with this protein is weaker than expected.
Recombinant Human FGF-10 (2 ug/lane) on SDS-PAGE under reducing (R) conditions. The gel was stained using Coomassie® Blue showing a single band at 20 kDa and purity greater than 95%. Note: Coomassie Blue staining with this protein is weaker than expected.

Recombinant Human FGF-10 Protein, Active, Low Endotoxin

Beta LifeScience SKU/CAT #: BEP-0037UL
/
Size

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Product Overview

Product Name Recombinant Human FGF-10 Protein
Target Symbol FGF10
Alternative Names Fibroblast Growth Factor 10, Keratinocyte Growth Gactor 2, KGF2
Accession Number O15520
Expression System E. coli.
Molecular Weight 19.6 kDa (predicted)
Sequence Cys37-Ser208, with an N-terminal Met
Purity >95% by SDS-PAGE and quantitative densitometry by Coomassie® Blue staining.
Activity Determined by a cell proliferation assay using 4MBr-5 rhesus monkey cells. The ED50 for this effect is typically 10-75 ng/mL.
Formulation Lyophilized from sterile PBS with Trehalose, DTT, and EDTA, pH 7.4
Endotoxin Level <0.02 EU per 1 ug of the protein as determined by the LAL method.
Shipping Shipped at ambient temperature.
Stability & Storage 12 months from date of receipt at -20°C to -70°C, lyophilized powder. 3 months at -20°C to -70°C under sterile conditions after reconstitution. Avoid repeated freeze-thaw cycles.
Reconstitution Reconstitute at 25 µg/mL in sterile PBS with 0.1% BSA.
Target Function Fibroblast Growth Factor 10 (FGF-10) is a protein involved in various developmental processes, particularly in embryogenesis and tissue regeneration. FGF-10 promotes branching morphogenesis of branched structures in several organs, including lungs, salivary glands, skin, pancreas, and mammary glands. Additionally, FGF-10 stimulates angiogenesis in during embryonic development, the maintenance of stem cell populations and facilitates tissue repair. FGF-10 primarily binds to FGF Receptor 2B (FGFR2B).
Tissue Specificity Lungs, salivary glands, skin, pancreas, inner ear, prostate and mammary glands.
Cellular Localization Secreted protein
Involvement In Disease Aberrant FGF-10 signaling has been implicated in several lung diseases, including pulmonary fibrosis, chronic obstructive pulmonary disease (COPD), and lung cancer. Dysregulated FGF-10 expression or signaling pathways can disrupt lung development and repair processes. Elevated FGF-10 expression or aberrant activation of FGF receptors (FGFRs) have been implicated in pancreatic, breast and prostate cancer tumor growth and metastasis.

FAQs

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Proteins are sensitive to heat, and freeze-drying can preserve the activity of the majority of proteins. It improves protein stability, extends storage time, and reduces shipping costs. However, freeze-drying can also lead to the loss of the active portion of the protein and cause aggregation and denaturation issues. Nonetheless, these adverse effects can be minimized by incorporating protective agents such as stabilizers, additives, and excipients, and by carefully controlling various lyophilization conditions.

Commonly used protectant include saccharides, polyols, polymers, surfactants, some proteins and amino acids etc. We usually add 8% (mass ratio by volume) of trehalose and mannitol as lyoprotectant. Trehalose can significantly prevent the alter of the protein secondary structure, the extension and aggregation of proteins during freeze-drying process; mannitol is also a universal applied protectant and fillers, which can reduce the aggregation of certain proteins after lyophilization.

Our protein products do not contain carrier protein or other additives (such as bovine serum albumin (BSA), human serum albumin (HSA) and sucrose, etc., and when lyophilized with the solution with the lowest salt content, they often cannot form A white grid structure, but a small amount of protein is deposited in the tube during the freeze-drying process, forming a thin or invisible transparent protein layer.

Reminder: Before opening the tube cap, we recommend that you quickly centrifuge for 20-30 seconds in a small centrifuge, so that the protein attached to the tube cap or the tube wall can be aggregated at the bottom of the tube. Our quality control procedures ensure that each tube contains the correct amount of protein, and although sometimes you can't see the protein powder, the amount of protein in the tube is still very precise.

To learn more about how to properly dissolve the lyophilized recombinant protein, please visit Lyophilization FAQs.

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