Recombinant Human Ferritin light chain Protein (His Tag)
Beta LifeScience SKU/CAT #: BLPSN-2023
Recombinant Human Ferritin light chain Protein (His Tag)
Beta LifeScience SKU/CAT #: BLPSN-2023
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|LFTD, MGC71996, NBIA3
|Ferritin, light polypeptide (FTL) is the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Storage of iron in the tissues occurs in the form of ferritin and hemosiderin. The latter originates from ferritin that has undergone intracellular digestion of its protein shell, leaving the iron core. Ferritin and hemosiderin are components of a continuum. Ferritin has been identified in all types of living organisms: animals, plants, molds, and bacteria. Whithin the protein shell of ferritin, iron is first oxidized to the ferric state for storage as ferric oxyhdroxide. Thus, ferritin removes excess iron from the cell sap where it could otherwise participate in peroxidation mechanisms.
|A DNA sequence encoding the human FTL (P02792) (Met 1-Asp 175) was expressed, with a His tag at the N-terminus.
|Predicted N Terminal
|Met 1-Asp 175
|The recombinant human FTL consisting of 191 a.a. and has a calculated molecular mass of 22.1 kDa. It migrates as an approximately 23 kDa band in SDS-PAGE under reducing conditions.
|>95% as determined by SDS-PAGE
|Please contact us for more information.
|Please contact us for detailed information
|Lyophilized from sterile 50mM Tris, 20% glycerol, pH 9.5.
|The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
|For Research Use Only
|Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney.
|Hyperferritinemia with or without cataract (HRFTC); Neurodegeneration with brain iron accumulation 3 (NBIA3); L-ferritin deficiency (LFTD)
Gene Functions References
- Mossbauer spectra of human liver ferritin and its pharmaceutical analogues Ferrum Lek and Maltofer(R) measured at various temperatures, are reported. PMID: 27372204
- Determining serum ferritin is a convenient and nonexpensive method to determine the outcome of the treatment of the cases with oral squamous cell carcinoma . Its potential as prognostic marker could not be overlooked PMID: 28862225
- The functional significance of the observed patch of carboxylate side chains and resulting metallocluster for biomineralization emerges from the lower iron oxidation rate measured in the E60AE61AE64A variant of human L-ferritin, leading to the proposal that the observed metallocluster corresponds to the suggested, but yet unobserved, nucleation site of L-ferritin PMID: 28202724
- The clinical measurement of ferritin in cerebrospinal fluid is a better biomarker than serum levels of ferritin for diagnosing and assessing the progression of amyotrophic lateral sclerosis patients. PMID: 27804118
- Our patient's transferrin saturation was 27% and HFE analysis revealed that she had neither H63D nor C282Y mutations that are known to predispose to hemochromatosis. Besides being an iron storage protein, ferritin is also one of the so-called acute phase proteins PMID: 28636169
- This is the first Australian report of the c.-167 C>T mutation in a large family with multiple affected individuals. PMID: 27096259
- Baseline serum ferritin (SF) did not influence bloodstream infections (BSIs), but higher levels resulted in more invasive fungal infections (IFIs) PMID: 28585071
- High serum ferritin expression is associated with metabolic syndrome. PMID: 27390880
- Hepatitis E virus ORF1 encoded macro domain protein interacts with light chain subunit of human ferritin and inhibits its secretion. PMID: 27170377
- indicate an important role of ferritin light chains in neurodegeneration PMID: 26994418
- This study demostrated that FTL mutation progressive brain iron dysregulation, morphological signs of early neurodegeneration and motor coordination deficits show PMID: 25447222
- FTL expression was higher in glioblastoma than in low-grade glioma, and decreased expression of FTL correlated with increased survival in glioblastoma patients. PMID: 26871431
- FTL gene mutation and persistent hyperferritinemia without iron deficiency anemia after phlebotomy PMID: 25720123
- Ferritin plasma levels increased significantly following stem cell transplantation in graft rejection patients. PMID: 26611853
- Single nucleotide polymorphisms in HAMP, BMP2, FTL and SLC40A1 genes have phenotype-modifying roles in hereditary hemochromatosis type 1. PMID: 25976471
- Genome-wide association study identifies variants in PMS1 associated with serum ferritin in a Chinese population. PMID: 25162662
- Urine ferritin levels are elevated significantly in systemic lupus erythematosus and correlate with disease activity. PMID: 22871034
- findings expand the genetic and clinical diversity of neuroferritinopathy and suggest CSF ferritin levels as a novel potential biochemical marker for the diagnosis of neuroferritinopathy. PMID: 24825732
- Plasma hepcidin-25 and ferritin light chain levels correlate with a malignant breast cancer diagnosis. PMID: 24306042
- provide a new mechanism for selective autophagy of ferritin and reveal a previously unappreciated role for autophagy and NCOA4 in the control of iron homeostasis in vivo PMID: 25327288
- Genetic testing confirmed the diagnosis of hereditary hyperferritinemia cataract syndrome (HHCS), demonstrating a C39>G (c.-161C>G) mutation into FTL gene. PMID: 24983587
- A c.-171C>G mutation in the iron-regulatory element of FTL was found in 2 members of a Spanish family with hyperferritinemia-cataract syndrome. PMID: 24022025
- Elevated cerebrospinal ferritin reliably (but unspecifically) indicates severe central nervous system disease. PMID: 24821637
- Through combining serum ferritin and MS spectral data, the diagnosis sensitivity and specificity of our model for prewarning severe aGVHD (III~IV degrees aGVHD) before transplant all increased to 90.0% PMID: 24195075
- Increased levels of ferritin light chain protein is associated with breast cancer. PMID: 23969999
- Together, our results suggest that iron can increase gamma-secretase activity through promoting the level of FTL that interacts with and stabilizes PEN-2 PMID: 23685131
- Elevated levels of ferritin are associated with type 2 diabetes mellitus. PMID: 23381919
- Data show the transcriptional regulation of the human ferritin gene by coordinated regulation of Nrf2 and protein arginine methyltransferases PRMT1 and PRMT4. PMID: 23699174
- Noncoding G-to-T transversion (c.-168G>T) located in the iron response element (IRE) of the gene coding for ferritin light chain (FTL) cosegregated with cataract in the family. PMID: 23592921
- The Badalona 36C > U and Heidelberg 52 G > C mutations within the L-ferritin Iron-Responsive Element only mildly alter the binding capacity of the Iron Regulatory Proteins but are still causative for hyperferritinaemia cataract syndrome. PMID: 23421845
- Elevation in ferritin is associated with response to trastuzumab in breast cancer. PMID: 23300545
- Plasma levels of FLT and S100A9 proteins are up-regulated and CNDP1 levels are down-regulated in patients with glioblastoma. PMID: 23029420
- data demonstrate an enhanced propensity of mutant ferritin to undergo iron-catalyzed oxidative damage and support this as a mechanism causing disruption of ferritin structure and iron mishandling that contribute to pathology of hereditary ferritinopathy PMID: 22348978
- Two novel missense L-ferritin variants are associated with hyperglycosylation, p.Gln26Ile and p.Ala27Val, and with benign hyperferritinemia in two unrelated patients. PMID: 22535864
- High ferritin is associated with poor treatment response in hematological neoplasms. PMID: 22248276
- The data strongly suggest that FTL and SCCA1 may serve as coreceptors in HBV cellular attachment and virus entry into hepatocytes. PMID: 22359459
- Molecular genetic analysis revealed point mutations within the FTL IRE. PMID: 22020773
- genetic variations in the HFE gene, but not plasma ferritin may have a role in coronary heart disease in Chinese PMID: 21696736
- Genetic analysis revealed mutation G32A in Pedigree 1 and mutation G32T in Pedigree 2, both heterozygous and located in the iron-responsive element of the ferritin light chain mRNA in hyperferritinemia cataract syndrome. PMID: 21907119
- FTL is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
- In the family with hyperferritinemia cataract syndrome a G-->C heterozygous mutation at position +32 of FTL was identified. PMID: 21541272
- Somatic mutations in the iron response elements (IRE) of the L-ferritin gene are infrequent in the age-related cataract. PMID: 21139976
- This protein has been found differentially expressed in thalami from patients with schizophrenia. PMID: 20471030
- Toluene diisocyanate (TDI) regulates haem oxygenase-1/ferritin expression: implications for toluene diisocyanate-induced asthma. PMID: 20345975
- biochemical and crystallographic characterization of pathogenic FTL mutant p.Phe167SerfsX26 showing that it is a functional ferritin with an altered conformation of the C terminus PMID: 20159981
- This protein has been found differentially expressed in the anterior cingulate cortex from patients with schizophrenia PMID: 20381070
- indicate that cellular iron imbalance and oxidative damage produced by the over-expression in of two pathogenic L-ferritin variants are primary causes of cell death, while aggregate formation is a secondary effect PMID: 19781644
- the x-ray crystallographic structure and report functional studies of ferritin homopolymers formed from the mutant FTL polypeptide PMID: 19923220
- Finding not only supports direct evidence for a regulatory role of L-ferritin in neuroectodermal cell pigmentation but also integrates a new player within a complicated network governing iron homeostasis in the dopamine neurons of substantia nigra. PMID: 19318681
- The genetic defects in the FTL gene are unlikely to be a common cause of typical PD, at least in a North America population. PMID: 12459518