Recombinant Human CD16b Protein (C-Fc-6His)
Beta LifeScience
SKU/CAT #: BL-0731NP

BL-0731NP: Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Recombinant Human CD16b Protein (C-Fc-6His)
Beta LifeScience
SKU/CAT #: BL-0731NP
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Description | Recombinant Human Low Affinity Immunoglobulin Gamma Fc Region Receptor III-B is produced by our Mammalian expression system and the target gene encoding Gly17-Gln208 is expressed with a human IgG1 Fc tag at the C-terminus. |
Accession | O75015 |
Synonym | Low affinity immunoglobulin gamma Fc region receptor III-B; Fc-gamma RIII-beta; FcR-10; IgG Fc receptor III-1; FCG3; FCGR3; CD16b; FCGR3B |
Gene Background | Low affinity immunoglobulin gamma Fc region receptor III-B, also known as Fc-gamma RIII-beta, FcR-10, IgG Fc receptor III-1, FCG3, FCGR3, CD16b and FCGR3B. FCGR3B is a GPI-anchor membrane protein and contains two Ig-like C2 type domains. FCGR3B can be expressed in orphonuclear leukocytes and stimulated eosinophils. FCGR3B can interact with INPP5D/SHIP1. FCGR3B localizes in the FCGR gene cluster is a CN polymorphic gene involved in the recruitment of polymorphonuclear neutrophils to sites of inflammation and their activation. FCGR3B may serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils. |
Molecular Mass | 48.8 KDa |
Apmol Mass | 70 KDa, reducing conditions |
Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
Endotoxin | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
Biological Activity | Not tested |
Reconstitution | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Storage | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. |
Usage | For Research Use Only |
Target Details
Target Function | Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils. |
Subcellular Location | Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Secreted after cleavage. |
Database References | HGNC: 3620 OMIM: 610665 KEGG: hsa:2215 STRING: 9606.ENSP00000294800 UniGene: PMID: 29137913 |