Recombinant Human Factor D Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-1958
Recombinant Human Factor D Protein (His Tag)

Recombinant Human Factor D Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-1958

Product Overview

Tag His
Host Species Human
Accession P00746
Synonym ADIPSIN, ADN, DF, FACTOR D, PFD
Background Complement factor D, also known as Adipsin, C3 convertase activator, Properdin factor D and CFD is a secreted protein which belongs to thepeptidase S1 family. CFD / Adipsin contains onepeptidase S1 domain. Complement factor D ( CFD / Adipsin ) is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. Complement factor D ( CFD / Adipsin ) has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology. This protein is also a serine protease that is secreted by adipocytes into the bloodstream. Complement factor D ( CFD / Adipsin ) cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. Complement factor D ( CFD / Adipsin ) is a serine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis. Defects in CFD / Adipsin are the cause of complement factor D deficiency (CFD deficiency) which predisposes to invasive meningococcal disease.
Description A DNA sequence encoding the mature form of human CFD (P00746) (Ile 26-Ala 253) was fused with a C-terminal His tag and a signal peptide at the N-terminus.
Source HEK293
Predicted N Terminal Ile 26
AA Sequence Ile 26-Ala 253
Molecular Weight The secreted recombinant human CFD consists of 239 a.a. and predicts a molecular mass of 25.8 kDa. As a result of glycosylation, rh CFD migrates as an approximately 33 kDa band in SDS-PAGE under reducing conditions.
Purity >97% as determined by SDS-PAGE
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Please contact us for detailed information
Formulation Lyophilized from sterile PBS, pH 7.4.
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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