Recombinant Human ESRP1/RBM35A Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-1942
Recombinant Human ESRP1/RBM35A Protein (His Tag)

Recombinant Human ESRP1/RBM35A Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-1942
Catalog No.: BLPSN-1942

Product Overview

Tag His
Host Species Human
Synonym RBM35A, RMB35A
Background Epithelial splicing regulatory protein 1 (ESRP1) is an epithelial cell-specific RNA binding protein that controls several key cellular processes, like alternative splicing and translation. Epithelial splicing regulatory protein 1 (ESRP1) has been characterized as an essential splicing factor required for the regulation of human pluripotency and differentiation. ESRP1 regulates CD44 alternative splicing during the EMT process which plays an important role in EOC carcinogenesis. In addition, ESRP1 is associated with disease prognosis in epithelial ovarian cancer (EOC). Epithelial splicing regulatory protein 1 (ESRP1) and 2 (ESRP2), epithelial cell-specific regulators of alternative splicing, are downregulated during the epithelial-mesenchymal transition (EMT). There is a critical role of the AS regulator epithelial splicing regulator protein 1 (ESRP1) for intestinal homeostasis and pathogenesis.
Description A DNA sequence encoding the human ESRP1 (NP_060167.2) (Met1-Ile681) was expressed with a His tag at the N-terminus.
Source Baculovirus-Insect Cells
Predicted N Terminal His
AA Sequence Met1-Ile681
Molecular Weight The recombinant human ESRP1 consists of 700 a.a. and predicts a molecular mass of 77.9 kDa.
Purity >65% as determined by SDS-PAGE.
Endotoxin < 1.0 EU per μg protein as determined by the LAL method.
Bioactivity Please contact us for detailed information
Formulation Lyophilized from sterile 20 mM Tris, 300 mM NaCl, pH 7.5, 10 % glycerol, 0.5 mM TCEP..
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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