Recombinant Human EIF4EBP1 Protein (His Tag)

Beta LifeScience SKU/CAT #: BL-0351NP
Recombinant Human EIF4EBP1 Protein (His Tag)

Recombinant Human EIF4EBP1 Protein (His Tag)

Beta LifeScience SKU/CAT #: BL-0351NP
Catalog No.: BL-0351NP

Product Overview

Tag His
Host Species Human
Accession Q13541
Synonym EIF4EBP1 Eukaryotic Translation Initiation Factor 4E-Binding Protein 1; 4E-BP1; eIF4E-Binding Protein 1; Phosphorylated Heat- and Acid-Stable Protein Regulated by Insulin 1; PHAS-I; EIF4EBP1
Background Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 (4EBP1) is a number of the eIF4E-binding protein family. 4EBP1 regulates eIF4E activity by preventing its assembly into the eIF4F complex. 4EBP1 mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. Non-phosphorylated 4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E. 4EBP1 is phosphorylated in response to various signals including insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. 4EBP1 has a role in progression of breast neoplasms through cell signaling.
Description Recombinant Human Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 is expressed by our E.coli expression system and the target gene encoding Met1-Ile118 is expressed with a His tag at the N-terminus.
Source E.coli
AA Sequence Met1-Ile118
Purity >90% as determined by reducing SDS-PAGE.
Endotoxin <0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Recombinant Human EIF4EBP1 Protein was lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Reconstitution Dissolve the lyophilized protein in distilled water.
Usage For Research Use Only
Storage Human EIF4EBP1 protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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