Recombinant Human EGFR Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1731
Recombinant Human EGFR Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1731
Catalog No.: BLPSN-1731
Product Overview
| Tag | Fc |
| Host Species | Human |
| Synonym | ERBB, ERBB1, HER1, mENA, NISBD2, PIG61 |
| Background | As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-alpha, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.Immune CheckpointImmunotherapyCancer ImmunotherapyTargeted Therapy |
| Description | A DNA sequence encoding the human EGFR (NP_001333870.1) (Met1-Lys375) was expressed with the Fc region of human IgG1 at the C-terminus. |
| Source | Baculovirus-Insect Cells |
| Predicted N Terminal | Leu 25 |
| AA Sequence | Met1-Lys375 |
| Molecular Weight | The recombinant human EGFR consists of 589 a.a. and predicts a molecular mass of 65.1 kDa. |
| Purity | >95% as determined by SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile 100 mM Glycine, 10 mM NaCl, pH 7.4.. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
