Recombinant Human EGFR Protein (Fc Tag)

Beta LifeScience SKU/CAT #: BLPSN-1731
Recombinant Human EGFR Protein (Fc Tag)

Recombinant Human EGFR Protein (Fc Tag)

Beta LifeScience SKU/CAT #: BLPSN-1731
Catalog No.: BLPSN-1731

Product Overview

Tag Fc
Host Species Human
Synonym ERBB, ERBB1, HER1, mENA, NISBD2, PIG61
Background As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-alpha, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.Immune CheckpointImmunotherapyCancer ImmunotherapyTargeted Therapy
Description A DNA sequence encoding the human EGFR (NP_001333870.1) (Met1-Lys375) was expressed with the Fc region of human IgG1 at the C-terminus.
Source Baculovirus-Insect Cells
Predicted N Terminal Leu 25
AA Sequence Met1-Lys375
Molecular Weight The recombinant human EGFR consists of 589 a.a. and predicts a molecular mass of 65.1 kDa.
Purity >95% as determined by SDS-PAGE.
Endotoxin < 1.0 EU per μg protein as determined by the LAL method.
Bioactivity Please contact us for detailed information
Formulation Lyophilized from sterile 100 mM Glycine, 10 mM NaCl, pH 7.4..
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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