Recombinant Human EGFR (A763_Y764insFQEA) Protein

Beta LifeScience SKU/CAT #: BL-0082SG
Recombinant Human EGFR (A763_Y764insFQEA) Protein

Recombinant Human EGFR (A763_Y764insFQEA) Protein

Beta LifeScience SKU/CAT #: BL-0082SG
Catalog No.: BL-0082SG

Product Overview

Tag GST
Host Species Human
Accession NM_005228
Synonym ERBB, mENA, ERBB1, HER1
Background EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival. Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms. Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation.
Description Recombinant human EGFR (A763_Y764insFQEA) (668-end) was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods.
Source Sf9 insect cells
AA Sequence 668a.a.-end
Molecular Weight 89~100 kDa
Purity For specific purity information on a given lot, see related COA.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Active
Formulation Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.
Stability The recombinant protein is stable for up to 12 months at -70°C
Usage For Research Use Only
Storage Recombinant Human EGFR (A763_Y764insFQEA) Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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