Recombinant Human ECSIT Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-1690
Recombinant Human ECSIT Protein (His Tag)

Recombinant Human ECSIT Protein (His Tag)

Beta LifeScience SKU/CAT #: BLPSN-1690
Catalog No.: BLPSN-1690

Product Overview

Tag His
Host Species Human
Accession Q9BQ95
Synonym SITPEC
Background ECSIT is an adapter protein of the toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Activation of NF-kappaB as a consequence of signaling through the Toll and IL-1 receptors is a major element of innate immune responses. ECSIT is specific for the Toll/IL-1 pathways and is a regulator of MEKK-1 processing. It bridges TRAF6 to MEKK-1. Expression of wild-type ECSIT accelerates processing of MEKK-1, whereas a dominant-negative fragment of ECSIT blocks MEKK-1 processing and activation of NF-kappaB. ECSIT is also required for normal embryonic development and efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase.
Description A DNA sequence encoding the human ECSIT (Q9BQ95-1)(Glu246-Ser431) was expressed with a His tag at the N-terminus.
Source E.coli
Predicted N Terminal His
AA Sequence Glu246-Ser431
Molecular Weight The recombinant human ECSIT consists of 201 a.a. and predicts a molecular mass of 22.9 KDa. It migrates as an approximately 25 KDa band in SDS-PAGE under reducing conditions.
Purity >90% as determined by SDS-PAGE
Endotoxin Please contact us for more information.
Bioactivity Please contact us for detailed information
Formulation Lyophilized from sterile 50mM Tris, 10% Glycerol, pH 8.0..
Stability The recombinant proteins are stable for up to 1 year from date of receipt at -70°C.
Usage For Research Use Only
Storage Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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