Recombinant Human E-Cadherin / ARC1 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1679
Recombinant Human E-Cadherin / ARC1 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1679
Catalog No.: BLPSN-1679
Product Overview
| Tag | His |
| Host Species | Human |
| Accession | NP_004351.1 |
| Synonym | Arc-1, CD324, CDH1, CDHE, E-cad, E-Cadherin, ECAD, LCAM, UVO |
| Background | Cadherins are calcium-dependent cell adhesion proteins which preferentially interact with themselves in a homophilic manner in connecting cells, and thus may contribute to the sorting of heterogeneous cell type. E-cadherin (E-Cad), also known as CDH1 and CD324, is a calcium-dependent cell adhesion molecule the intact function of which is crucial for the establishment and maintenance of epithelial tissue polarity and structural integrity. Mutations in CDH1 occur in diffuse type gastric cancer, lobular breast cancer, and endometrial cancer. In human cancers, partial or complete loss of E-cadherin expression correlates with malignancy. During apoptosis or with calcium influx, E-Cad is cleaved by the metalloproteinase to produce fragments of about 38 kDa (E-CAD/CTF1), 33 kDa (E-CAD/CTF2) and 29 kDa (E-CAD/CTF3), respectively. E-Cad has been identified as a potent invasive suppressor, as downregulation of E-cadherin expression is involved in dysfunction of the cell-cell adhesion system, and often correlates with strong invasive potential and poor prognosis of human carcinomas. |
| Description | A DNA sequence encoding the human CDH1 (NP_004351.1) (Asp155-Ala709) was expressed with a His tag at the C-terminus. |
| Source | HEK293 |
| Predicted N Terminal | Asp 155 |
| AA Sequence | Asp155-Ala709 |
| Molecular Weight | The recombinant human CDH1 consists of 566 a.a. and predicts a molecular mass of 62 kDa. |
| Purity | >90% as determined by SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4.. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
