Recombinant Human DUSP22 (MKPX) Protein

Beta LifeScience SKU/CAT #: BL-0196SG
Recombinant Human DUSP22 (MKPX) Protein

Recombinant Human DUSP22 (MKPX) Protein

Beta LifeScience SKU/CAT #: BL-0196SG
Catalog No.: BL-0196SG

Product Overview

Tag GST
Host Species Human
Accession NM_020185
Synonym VHX, JKAP, JSP1, MKPX
Background Dual specificity phosphatases (DUSP) family, which can dephosphorylate both phosphoserine/threonine and phosphotyrosine residues, comprise of two subgroups: "typical" DUSP (include 11 MKPs that dephosphorylate the mitogen-activated protein kinases Erk, Jnk, and p38 at their dually phosphorylated TXY activation loop motif) and "atypical" DUSP (include 8 enzymes that lack specific MAP kinase-targeting motifs and tend to be much smaller proteins, which are less than 250 amino acid residues) (1). DUSP22, also called JKAP, JSP1 and MKPX plays a role in various inflammatory and proliferative disorders associated with dysfunctional Jnk signaling (2).
Description Recombinant full length human DUSP22 was produced in E. coli using a N-terminual GST tag. This protein is purified with our unique purification methods.
Source E.coli
AA Sequence Full Length
Molecular Weight ~43 kDa
Purity For specific purity information on a given lot, see related COA.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Active
Formulation Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.
Stability The recombinant protein is stable for up to 12 months at -70°C
Usage For Research Use Only
Storage Recombinant Human DUSP22 (MKPX) Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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