Recombinant Human DPEP1 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1643
Recombinant Human DPEP1 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1643
Catalog No.: BLPSN-1643
Product Overview
| Tag | His |
| Host Species | Human |
| Accession | P16444 |
| Synonym | MBD1, MDP, RDP |
| Background | Dehydropeptidase-I, also known as DPEP1, is a kidney membrane enzyme. Its expression in normal colonic mucosa is very low, but it is highly expressed in colorectal adenoma and cancer specimens and is negatively correlated with parameters of pathological aggressiveness and poor prognosis. The overexpression of DPEP1 suppressed tumor cells invasiveness and increased sensitivity to chemotherapeutic agent Gemcitabine. Growth factor EGF treatment decreased DPEP1 expression. Dehydropeptidase-I may be a candidate target in PDAC for designing improved treatments. It uses zinc as a cofactor and acts as a disulfide-linked homodimer. |
| Description | A DNA sequence encoding the human DPEP1 (P16444) (Met1-Ser385) was expressed with a His tag at the C-terminus. |
| Source | HEK293 |
| Predicted N Terminal | Asp 17 |
| AA Sequence | Met1-Ser385 |
| Molecular Weight | The recombinant human DPEP1 consists of 380 a.a. and predicts a molecular mass of 42.5 KDa. It migrates as an approximately 44-47 KDa band in SDS-PAGE under reducing conditions. |
| Purity | >95% as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
