Recombinant Human Decorin Protein
Beta LifeScience
SKU/CAT #: BLPSN-1583
Recombinant Human Decorin Protein
Beta LifeScience
SKU/CAT #: BLPSN-1583
Catalog No.: BLPSN-1583
Product Overview
| Tag | N/A |
| Host Species | Human |
| Accession | NP_001911.1 |
| Synonym | CSCD, DSPG2, PG40, PGII, PGS2, SLRR1B |
| Background | Decorin is a ubiquitous small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a core protein and a covalently linked glycosaminoglycan chain which is either chondroitin sulfate (CS) or dermatan sulfate (DS). As a component of connective tissue, decorin interacts with several extracellular matrix components, such as type I collagen and fibronectin, and plays a role in matrix assembly. Decorin resides in the tumor microenvironment and affects the biology of various types of cancer by downregulating the activity of several receptors involved in cell growth and survival. Decorin binds to and modulates the signaling of the epidermal growth factor receptor and other members of the ErbB family of receptor tyrosine kinases. It exerts its antitumor activity by a dual mechanism: via inhibition of these key receptors through their physical downregulation coupled with attenuation of their signaling, and by binding to and sequestering TGFbeta. Decorin also modulates the insulin-like growth factor receptor and the low-density lipoprotein receptor-related protein 1, which indirectly affects the TGFbeta receptor pathway. Decorin plays significant roles in tissue development and assembly, as well as playing both direct and indirect signaling roles. |
| Description | A DNA sequence encoding the human DCN (NP_001911.1) (Met1-Lys359) was expressed. |
| Source | HEK293 |
| Predicted N Terminal | Gly 17 |
| AA Sequence | Met1-Lys359 |
| Molecular Weight | The recombinant human DCN consists of 343 a.a. and predicts a molecular mass of 38 kDa. |
| Purity | Greater than95% as determined by SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4.. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
