Recombinant Human DCAMKL1 Protein
Beta LifeScience
SKU/CAT #: BL-0136SG
Recombinant Human DCAMKL1 Protein
Beta LifeScience
SKU/CAT #: BL-0136SG
Catalog No.: BL-0136SG
Product Overview
| Tag | his |
| Host Species | Human |
| Accession | NM_004734 |
| Synonym | DCLK1; DCDC3A; DCLK; KIAA0369 |
| Background | DCAMKL1 or doublecortin-like kinase 1 contains two N-terminal doublecortin domains (which bind microtubules and regulate microtubule polymerization), a C-terminal serine/threonine protein kinase domain (which shows substantial homology to Ca2+/calmodulin-dependent protein kinase), and a serine/proline-rich domain in between the doublecortin and the protein kinase domains (which mediates multiple protein-protein interactions) (1). DCAMKL1 is a microtubule-associated kinase that can undergo autophosphorylation. DCAMKL1 has microtubule-polymerizing activity that is independent of its protein kinase activity (2). DCAMKL1 is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. |
| Description | Full-length recombinant human DCAMKL1 was produced by baculovirus in Sf9 cells, fused with a His tag at N-terminus. |
| Source | Sf9 insect cells |
| AA Sequence | Full Length |
| Molecular Weight | 85 kDa |
| Purity | For specific purity information on a given lot, see related COA. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Bioactivity | Active |
| Formulation | Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol. |
| Stability | The recombinant protein is stable for up to 12 months at -70°C |
| Usage | For Research Use Only |
| Storage | Recombinant Human DCAMKL1 Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
