Recombinant Human DCAMKL1 Protein

Beta LifeScience SKU/CAT #: BL-0136SG
Recombinant Human DCAMKL1 Protein

Recombinant Human DCAMKL1 Protein

Beta LifeScience SKU/CAT #: BL-0136SG
Catalog No.: BL-0136SG

Product Overview

Tag his
Host Species Human
Accession NM_004734
Synonym DCLK1; DCDC3A; DCLK; KIAA0369
Background DCAMKL1 or doublecortin-like kinase 1 contains two N-terminal doublecortin domains (which bind microtubules and regulate microtubule polymerization), a C-terminal serine/threonine protein kinase domain (which shows substantial homology to Ca2+/calmodulin-dependent protein kinase), and a serine/proline-rich domain in between the doublecortin and the protein kinase domains (which mediates multiple protein-protein interactions) (1). DCAMKL1 is a microtubule-associated kinase that can undergo autophosphorylation. DCAMKL1 has microtubule-polymerizing activity that is independent of its protein kinase activity (2). DCAMKL1 is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis.
Description Full-length recombinant human DCAMKL1 was produced by baculovirus in Sf9 cells, fused with a His tag at N-terminus.
Source Sf9 insect cells
AA Sequence Full Length
Molecular Weight 85 kDa
Purity For specific purity information on a given lot, see related COA.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Active
Formulation Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.
Stability The recombinant protein is stable for up to 12 months at -70°C
Usage For Research Use Only
Storage Recombinant Human DCAMKL1 Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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