Recombinant Human Dan Domain Family Member 5 (DAND5) Protein (His-SUMO)
Beta LifeScience
SKU/CAT #: BLC-09835P

Greater than 90% as determined by SDS-PAGE.
Recombinant Human Dan Domain Family Member 5 (DAND5) Protein (His-SUMO)
Beta LifeScience
SKU/CAT #: BLC-09835P
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Description | Recombinant Human Dan Domain Family Member 5 (DAND5) Protein (His-SUMO) is produced by our E.coli expression system. This is a full length protein. |
Purity | Greater than 90% as determined by SDS-PAGE. |
Uniprotkb | Q8N907 |
Target Symbol | DAND5 |
Synonyms | BMP antagonist 3; CER2; cerberus 2; Cerberus like 2; Cerberus-like protein 2; Cerl-2; CERL2; CKTSF1B3; COCO; CRL2; Cysteine knot superfamily 1; Cysteine knot superfamily 1 BMP antagonist 3; DAN domain family member 5; Dand5; DAND5_HUMAN; DANTE; GREM3; Gremlin-3; MGC126849; SP1 |
Species | Homo sapiens (Human) |
Expression System | E.coli |
Tag | N-6His-SUMO |
Target Protein Sequence | RPEPQSPRPQSWAAANQTWALGPGALPPLVPASALGSWKAFLGLQKARQLGMGRLQRGQDEVAAVTLPLNPQEVIQGMCKAVPFVQVFSRPGCSAIRLRNHLCFGHCSSLYIPGSDPTPLVLCNSCMPARKRWAPVVLWCLTGSSASRRRVKISTMLIEGCHCSPKA |
Expression Range | 23-189aa |
Protein Length | Full Length of Mature Protein |
Mol. Weight | 34.1kDa |
Research Area | Others |
Form | Liquid or Lyophilized powder |
Buffer | Liquid form: default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
Reconstitution | Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
Storage | 1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
Target Details
Target Function | Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth and differentiation. |
Subcellular Location | Secreted. |
Protein Families | DAN family |
Database References |
Gene Functions References
- High DAND5 expression is associated with tumor growth and angiogenesis in breast cancer. PMID: 26908452
- In this work, we report two patients with a DAND5 heterozygous non-synonymous variant (c.455G > A) in the functional domain of the DAND5 protein (p.R152H), a master regulator of Nodal signaling. Patient 1 presents left isomerism, ventricular septal defect with overriding aorta and pulmonary atresia, while patient 2 presents ventricular septal defect with overriding aorta, right ventricular hypertrophy PMID: 28738792
- A gain-of-function cDNA screen reveals that Coco, a secreted antagonist of TGF-beta ligands, induces dormant breast cancer cells to undergo reactivation in the lung. PMID: 22901808