Recombinant Human Cyclophilin A / CYPA Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1522
Recombinant Human Cyclophilin A / CYPA Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1522
Catalog No.: BLPSN-1522
Product Overview
| Tag | His |
| Host Species | Human |
| Accession | P62937 |
| Synonym | CYPA, CYPH, HEL-S-69p |
| Background | Peptidyl-prolyl cis-trans isomerase A, also known as PPIase A, Rotamase A, Cyclophilin A, Cyclosporin A-binding protein, PPIA and CYPA, is a cytoplasm protein which belongs to thecyclophilin-type PPIase family and PPIase A subfamily. Cyclophilins (CyPs) are a family of proteins found in organisms ranging from prokaryotes to humans. These molecules exhibit peptidyl-prolyl isomerase activity, suggesting that they influence the conformation of proteins in cells. PPIA / Cyclophilin A accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. PPIA / Cyclophilin A is secreted by vascular smooth muscle cells in response to inflammatory stimuli, and could thus contribute to atherosclerosis. It is not essential for mammalian cell viability. PPIA / Cyclophilin A can interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. |
| Description | A DNA sequence encoding the human PPIA (P62937) (Met 1-Glu 165) was expressed, with a His tag at the C-terminus. |
| Source | E.coli |
| Predicted N Terminal | Met 1 |
| AA Sequence | Met 1-Glu 165 |
| Molecular Weight | The recombinant human PPIA consisting of 175 a.a. and has a calculated molecular mass of 19.4 kDa as estimated in SDS-PAGE under reducing conditions. |
| Purity | >97% as determined by SDS-PAGE |
| Endotoxin | Please contact us for more information. |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile 50mM Tris, 150mM NaCl, 20% glycerol, pH 7.7. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
