Recombinant Human CTSB Protein (His Tag)
Beta LifeScience
SKU/CAT #: BL-0314NP
Recombinant Human CTSB Protein (His Tag)
Beta LifeScience
SKU/CAT #: BL-0314NP
Catalog No.: BL-0314NP
Product Overview
| Tag | His |
| Host Species | Human |
| Accession | P07858 |
| Synonym | CTSB Cathepsin B; APP Secretase; APPS; Cathepsin B1; CTSB; CPSB |
| Background | Cathepsin B is an enzymatic protein belonging to the peptidase (or protease) families. The protein encoded by this gene is a lysosomal cysteine protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is a member of the peptidase C1 family. At least five transcript variants encoding the same protein have been found for this gene. Cystatin-B / CSTB is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B. Cystatin-B / CSTB is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. Cystatin-B / CSTB is also thought to play a role in protecting against the proteases leaking from lysosomes |
| Description | Recombinant Human Cathepsin B is expressed by our Mammalian expression system and the target gene encoding Arg18-Ile339 is expressed with a His tag at the C-terminus. |
| Source | Human Cells |
| AA Sequence | Arg18-Ile339 |
| Purity | >95% as determined by reducing SDS-PAGE. |
| Endotoxin | <0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Bioactivity | Measured by its ability to cleave the fluorogenic peptide substrate Z-LR-AMC Specific Activity is greater than 3000 pmol/min/ug |
| Formulation | Recombinant Human CTSB Protein was supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0. |
| Usage | For Research Use Only |
| Storage | Human CTSB protein should be stored at < -20°C, stable for 6 months after receipt.Please minimize freeze-thaw cycles. |
