Recombinant Human CRIPT Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1429
Recombinant Human CRIPT Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1429
Catalog No.: BLPSN-1429
Product Overview
| Tag | His |
| Host Species | Human |
| Accession | Q9P021 |
| Synonym | HSPC139, SSMDF |
| Background | CRIPT, also known as cysteine-rich PDZ-binding protein, belongs to the CRIPT family. It interacts with TUBB1. CRIPT also interacts strongly with the PDZ3 domain of members of the DLG4 family. It is involved in the cytoskeletal anchoring of DLG4 in excitatory synapses. CRIPT is highly conserved from mammals to plants and binds selectively to the third PDZ domain (PDZ3) of PSD-95 via its C terminus. n heterologous cells, CRIPT causes a redistribution of PSD-95 to microtubules. In brain, CRIPT colocalizes with PSD-95 in the postsynaptic density and can be coimmunoprecipitated with PSD-95 and tubulin. These findings suggest that CRIPT may regulate PSD-95 interaction with a tubulin-based cytoskeleton in excitatory synapses. |
| Description | A DNA sequence encoding the mature form of human CRIPT (Q9P021) (Met1-Val101) was expressed with a His tag at the N-terminus. |
| Source | E.coli |
| Predicted N Terminal | His |
| AA Sequence | Met1-Val101 |
| Molecular Weight | The recombinant human CRIPT consists of 116 a.a. and predicts a molecular mass of 13.1 KDa. It migrates as an approximately 17 KDa band in SDS-PAGE under reducing conditions. |
| Purity | >90% as determined by SDS-PAGE |
| Endotoxin | Please contact us for more information. |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4.. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
