Recombinant Human CRIP2 Protein
Beta LifeScience
SKU/CAT #: BLPSN-1427
Recombinant Human CRIP2 Protein
Beta LifeScience
SKU/CAT #: BLPSN-1427
Catalog No.: BLPSN-1427
Product Overview
| Tag | N/A |
| Host Species | Human |
| Accession | P52943 |
| Synonym | CRIP, CRP2, ESP1 |
| Background | CRIP2 is a putative transcription factor. It has a widespread tissue expression and is highly expressed in heart. CRIP2 contains two LIM zinc-binding domains. CRIP2 may participate in the differentiation of smooth muscle tissue. It also plays an important role in esophageal squamous cell carcinoma (ESCC) tumorigenesis. CRIP2 acts as a transcription repressor of the NF-κB-mediated proangiogenic cytokine expression and thus functionally inhibits tumor formation and angiogenesis. It interacts with the NF-κB/p65 to inhibit its DNA-binding ability to the promoter regions of the major proangiogenesis cytokines critical for tumor progression, including IL6, IL8, and VEGF. In conclusion, we provide compelling evidence that CRIP2 acts as a transcription repressor of the NF-κB-mediated proangiogenic cytokine expression and thus functionally inhibits tumor formation and angiogenesis. |
| Description | A DNA sequence encoding the human CRIP2 (P52943) (Met1-Pro208) was expressed and purified. |
| Source | Baculovirus-Insect Cells |
| Predicted N Terminal | Gly |
| AA Sequence | Met1-Pro208 |
| Molecular Weight | The recombinant human CRIP2 consists of 210 a.a. and predicts a molecular mass of 22.6 KDa. It migrates as an approximately 26 KDa band in SDS-PAGE under reducing conditions. |
| Purity | >95% as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile 20mM Tris, 500mM Nacl, 10% glycerol, pH 7.4.. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
