Recombinant Human CLEC10A Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1295
Recombinant Human CLEC10A Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1295
Catalog No.: BLPSN-1295
Product Overview
| Tag | Fc |
| Host Species | Human |
| Accession | Q8IUN9 |
| Synonym | CD301, CLECSF13, CLECSF14, HML, HML2, MGL |
| Background | CLEC1A, also known as the macrophage galactose-type calcium-type lectins (MGLs; CD31) constitute a unique class of C-type lectins because of their specificity for galactose and its structural homologues. MGLs/CD31 is a type II transmembrane glycoproteins and is expressed on macrophages and related cells of myeloid origins, particularly immature dendritic cells (DCs). There are 2 homologues: MGL1 and MGL2 (CD31a and CD31b) in mice. MGL1/CD31a induces both the production and secretion of interleukin (IL)-1. MGL1/CD31a plays a protective role against colitis by effectively inducing IL-1 production by colonic lamina propria macrophages in response to invading commensal bacteria. |
| Description | A DNA sequence encoding the human CLEC10A (Q8IUN9-2) (Gln61-His292) was expressed, with the fused Fc region of human IgG1 at the N-terminus. |
| Source | HEK293 |
| Predicted N Terminal | Glu |
| AA Sequence | Gln61-His292 |
| Molecular Weight | The recombinant human CLEC10A/Fc is a disulfide-linked homodimer. The reduced monomer comprises 492 a.a. and has a predicted molecular mass of 54.6 kDa. The apparent molecular mass of the protein is approximately 58 kDa in SDS-PAGE under reducing conditions due to glycosylation. |
| Purity | >85% as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
