Recombinant Human chymase 1 / MCT1 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1266
Recombinant Human chymase 1 / MCT1 Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1266
Catalog No.: BLPSN-1266
Product Overview
| Tag | His |
| Host Species | Human |
| Accession | P23946 |
| Synonym | chymase, CYH, MCT1 |
| Background | The STR polymorphism in the CMA1 gene is associated with asthma and that this association is even stronger with atopic asthma. CMA1 and IL-4 in atopic asthma and for IL-4 in atopy in general. The local angiotensin II system (LAS) has numerous functions, including the regulation of growth and differentiation in the gastrointestinal tract. Angiotensin II (AngII) may be generated by angiotensin-I-converting enzyme (ACE) or mast cell chymase (CMA1) and plays an important role in inflammatory processes, although opinions differ as to which AngII-generating enzyme is primarily associated with AngII-mediated effects. ACE in the gastric mucosa and the microvasculature of granulation tissue may represent a novel therapeutic target for the promotion of healing processes in gastritis and ulceration using ACE inhibitors or AT1R antagonists. The gene for mast cell chymase (CMA1) is an ideal candidate for investigating genetic predisposition to atopic asthma, as it is an important mediator of inflammation and remodeling in the asthmatic lung. (CMA1) is important for the generation of angiotensin II and therefore might be associated with the pathogenesis of hypertension. |
| Description | A DNA sequence encoding the human CMA1 (P23946) (Met 1-Asn 247) was fused with a His tag at the C-terminus. |
| Source | Baculovirus-Insect Cells |
| Predicted N Terminal | Gly 20 |
| AA Sequence | Met 1-Asn 247 |
| Molecular Weight | The secreted recombinant human CMA1 consists of 238 a.a. and predicts a molecular mass of 26.6 kDa. It migrates as an approximately 33 kDa band in SDS-PAGE under reducing conditions. |
| Purity | >92% as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% gly. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
