Recombinant Human CHRNB3 Protein (ECD, Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1260
Recombinant Human CHRNB3 Protein (ECD, Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1260
Catalog No.: BLPSN-1260
Product Overview
| Tag | Fc |
| Host Species | Human |
| Accession | NP_000740.1 |
| Background | Cholinergic nicotinic receptor (CHRN) gene family has been known to mediate the highly additive effects of nicotine in the body, and implicated nicotine dependence (ND) and related phenotypes. Cigarette smoking is protective in Parkinson's disease (PD), possibly because of nicotine action on brain nicotinic-acetylcholine receptors. The beta3 nicotinic-acetylcholine receptor subunit (encoded by CHRNB3) is depleted in the striatum of PD patients and associated with nicotine dependence. |
| Description | A DNA sequence encoding the human CHRNB3 (NP_000740.1) (Met1-Leu232) was expressed with the Fc region of human IgG1 at the C-terminus. |
| Source | HEK293 |
| Predicted N Terminal | Ile 25 |
| AA Sequence | Met1-Leu232 |
| Molecular Weight | The recombinant human CHRNB3 consists 446 a.a. and predicts a molecular mass of 51 kDa. |
| Purity | >85% as determined by SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4.. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
