Recombinant Human CAPG Protein
Beta LifeScience
SKU/CAT #: BLPSN-0541
Recombinant Human CAPG Protein
Beta LifeScience
SKU/CAT #: BLPSN-0541
Collections: Other recombinant proteins, Recombinant proteins
Our products are highly customizable to meet your specific needs. You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. Submitting a written inquiry expedites the quoting process.
Product Overview
Tag | N/A |
Host Species | Human |
Accession | AAH14549.1 |
Synonym | AFCP, HEL-S-66, MCP |
Background | CAPG, also known as actin Regulatory Protein CAPG, is a a member of the gelsolin/villin family. Members of this family are actin-regulatory proteins. CAPG reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, CAPG contributes to the control of actin-based motility in non-muscle cells. CAPG may also play an important role in macrophage function. |
Description | A DNA sequence encoding human CAPG(AAH14549.1) (Met1-Lys348) was expressed. |
Source | E.coli |
Predicted N Terminal | Met |
AA Sequence | Met1-Lys348 |
Molecular Weight | The recombinant human CAPG consists of 348 a.a. and predicts a molecular mass of 38.5 KDa. It migrates as an approximately 43 KDa band in SDS-PAGE under reducing conditions. |
Purity | >95% as determined by SDS-PAGE |
Endotoxin | Please contact us for more information. |
Bioactivity | Please contact us for detailed information |
Formulation | Lyophilized from sterile 20mM tris, 10% glycerol, pH 8.0.. |
Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
Usage | For Research Use Only |
Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Target Details
Target Function | Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA. |
Subcellular Location | Nucleus. Cytoplasm. Melanosome. Cell projection, lamellipodium. Cell projection, ruffle. |
Protein Families | Villin/gelsolin family |
Database References | |
Tissue Specificity | Macrophages and macrophage-like cells. |
Gene Functions References
- Study suggested that CapG could be used as a biomarker for metastatic CRC in the clinical specimens. Moreover, our in vitro study demonstrated that CapG might contribute on tumor metastasis in human CRCs. PMID: 30155403
- Results revealed that CapG is a novel independent prognostic predictor for glioma patients and highlight a key role of CapG in proliferation and metastasis of glioma. PMID: 29399702
- it is demonstrated that CapG is expressed in the cytoplasm and could be used as a prognostic or diagnostic biomarker for mHCC in clinical specimens PMID: 29970516
- The combination of CTNB1, XPO2, and CAPG achieved 95% sensitivity and 96% specificity for the discrimination of these subtypes. We developed two uterine aspirate-based signatures to diagnose Endometrial cancer and classify tumors in the most prevalent histologic subtypes. This will improve diagnosis and assist in the prediction of the optimal surgical treatment PMID: 28790116
- Overexpression of CAPG is associated with glioma. PMID: 26663173
- On the basis of these results, we propose a model in which dynamic vimentin filaments target CARMIL2 to critical membrane-associated locations, where CARMIL2 regulates CP, and thus actin assembly, to create cell protrusions PMID: 26466680
- The composite biomarker, CAPG and GIPC1 in primary breast tumors, predicted disease outcomes and benefit from zoledronate and may facilitate patient selection for adjuvant bisphosphonate treatment. PMID: 26757732
- A single nucleotide polymorphism rs6886 inside the CapG gene was identified, affecting a CapG phosphorylation site and thus potentially modifying CapG function. PMID: 24804218
- CapG was up-regulated in the tumor tissues of patients with lymph node metastasis (LNM), whereas it showed an equivalent expression level between non-tumor and tumor tissues of patients without LNM. PMID: 23782053
- CapG is involved in the process of metastasis by promoting the invasiveness of tumor cells. PMID: 23085225
- CapG was identified as a novel candidate biomarker to predict response to gemcitabine treatment and survival in cholangiocarcinoma. PMID: 22155129
- Expression of CapG, gelsolin, and P-gp was found to be associated with an increased risk of death from non-small cell lung cancer. PMID: 22190510
- These results suggest that overexpression of CapG may be associated with progression of lung adenocarcinoma. PMID: 21908955
- strong down-regulation of MCK activity contributes to F-actin instability and induces post-translational modification of alphaB-crystallin and desmin PMID: 21768101
- CapG was upregulated in the stroma cells of nasopharyngeal carcinoma (NPC) compared with normal nasopharyngeal epithelial tissues. CapG possibly plays a role in the complex interaction between NPC cells and the surrounding host tissue. PMID: 19242827
- Proteomic study of macrophages exposed to oxLDL identifies a CAPG polymorphism associated with carotid atherosclerosis. PMID: 19439302
- CapG lacks a nuclear export sequence present in structurally related proteins PMID: 12637565
- importin-beta-dependent nuclear import of the actin modulating protein CapG promotes cell invasion PMID: 15454578
- CapG is a new tumor suppressor gene involved in the tumorigenic progression of certain cancers PMID: 16767159
- Comprehension of the mobility and compartmentalization of the CapG protein in normal and in cancer cells in vivo could constitute a new basis to characterize the invasiveness and metastasizing potential of breast cancer. PMID: 18059028
- Dysregulated expression of gelsolin-like actin capping protein(CapG) was found in premalignant and malignant oral carcinogenesis. PMID: 18237446
- Results report that NTF2 and Ran control nuclear import of the filamentous actin capping protein CapG. PMID: 18266911
- CapG mobility in cell nuclei of live breast cancer cells PMID: 18461482
- the 4 biomarkers CLU, ITGB3, PRAME and CAPG may be used as prognostic factors for patients with stage III serous ovarian adenocarcinomas. PMID: 18709641
- These results suggest that filamentous actin in the nucleolus might be regulated by actin binding proteins such as CapG. PMID: 18938132
- several genes that are known to be regulated by DNA methylation were up-regulated dramatically by integrin alpha6beta4 expression, including S100A4, FST, PDLIM4, CAPG, and Nkx2.2. PMID: 19011242
- A role for the actin-binding protein CapG as a mediator of cross-talk between the actin cytoskeleton and microtubule-based organelles that regulate cell division was proposed. PMID: 19166812
- Hypoxia-inducible factor 1alpha up-regulated CapG protein expression under normoxia. Knockdown of HIF-1alpha expression in hPASMCs also inhibited hypoxia-induced CapG up-regulation. PMID: 19188659