Recombinant Human CALCB Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-0516
Recombinant Human CALCB Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-0516
Catalog No.: BLPSN-0516
Product Overview
| Tag | Fc |
| Host Species | Human |
| Accession | P10092 |
| Synonym | CALC2, CGRP-II, CGRP2 |
| Background | CALCB, also known as CGPR and calcitonin 2, belongs to the calcitonin family. CALCB is a calcitonin (CT) peptide which may play a role in the mediation of human inflammatory diseases. It is highly expressed in the skin, blood, and cerebrospinal fluid. CGRP immunolabeling (IL) was detected in epidermal keratinocytes at levels that were especially high and widespread in the skin of humans from locations afflicted with postherpetic neuralgia (PHN) and complex region pain syndrome type 1 (CRPS), of monkeys infected with simian immunodeficiency virus, and of rats subjected to L5/L6 spinal nerve ligation, sciatic nerve chronic constriction, and subcutaneous injection of complete Freund's adjuvant. Increased CGRP-IL was also detected in epidermal keratinocytes of transgenic mice with keratin-14 promoter driven overexpression of noggin, an antagonist to BMP-4 signaling. CGPR dilates a variety of vessels including the coronary, cerebral and systemic vasculature. |
| Description | A DNA sequence encoding the human CALCB (P10092) (Met1-Phe118) was fused with Fc region of mouse IgG at the C-terminus. |
| Source | HEK293 |
| Predicted N Terminal | Ala 26 |
| AA Sequence | Met1-Phe118 |
| Molecular Weight | The recombinant human CALCB/mFc is a disulfide-linked homodimer. The reduced monomer comprises 327 a.a. and has a predicted molecular mass of 36.2 kDa. The apparent molecular mass of the protein is approximately 37 in SDS-PAGE under reducing conditions. |
| Purity | >95% as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4.. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
