Recombinant Human c-MET Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1339
Recombinant Human c-MET Protein (Fc Tag)
Beta LifeScience
SKU/CAT #: BLPSN-1339
Catalog No.: BLPSN-1339
Product Overview
| Tag | Fc |
| Host Species | Human |
| Synonym | AUTS9, c-Met, DFNB97, HGFR, RCCP2 |
| Background | Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that has been shown to be overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.Immune CheckpointImmunotherapyCancer ImmunotherapyTargeted Therapy |
| Description | A DNA sequence encoding the extracellular domain (Met 1-Thr 932) of human c-Met (NP_000236) was fused with the C-terminal His-tagged Fc region of human IgG1 at the C-terminus. The purified protein was biotinylated in vitro. |
| Source | HEK293 |
| Predicted N Terminal | Glu 25 |
| AA Sequence | NP_000236 |
| Molecular Weight | The mature recombinant human c-Met/Fc is a disulfide-linked tetramer composed of two proteolytically cleaved alpha and beta subunits. Each alpha and beta together with the C-terminal Fc tag consists of 1155 a.a. and has a predicted molecular mass of 129.5 (alpha =32.5 + Fc tagged beta=97) kDa. |
| Purity | >95% as determined by SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
