Recombinant Human BRAF (R506_K507insVLR) Protein

Beta LifeScience SKU/CAT #: BL-0244SG
Recombinant Human BRAF (R506_K507insVLR) Protein

Recombinant Human BRAF (R506_K507insVLR) Protein

Beta LifeScience SKU/CAT #: BL-0244SG
Catalog No.: BL-0244SG

Product Overview

Tag GST
Host Species Human
Accession NM_004333
Synonym BRAF (Ex9-18), BRAF1, RAFB1, B-raf, B-raf 1, MGC126806, MGC138284
Background BRAF is a member of the RAF family that is activated by members of the Ras family upon growth factor-induced stimulation. Active Ras can induce heterodimerization of cRaf and BRAF and this may explain the observed cooperativity of cRaf and BRAF in cells responding to growth factor signals (1). Activating mutations in the BRAF gene are present in a large percentage of human malignant melanomas and in a proportion of colon cancers. The vast majority of these mutations result in a valine to glutamic acid change at residue 599 within the activation segment of BRAF (2).
Description Recombinant human BRAF (R506_K507insVLR) (381-end or exon 9-18) protein was produced by baculovirus in Sf9 insect cells, fused with a GST tag at N-terminus. This protein is purified with our unique purification methods.
Source Sf9 insect cells
AA Sequence 381a.a.-end or exon 9-18
Molecular Weight ~69 kDa
Purity For specific purity information on a given lot, see related COA.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
Bioactivity Active
Formulation Recombinant protein is supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.
Stability The recombinant protein is stable for up to 12 months at -70°C
Usage For Research Use Only
Storage Recombinant Human BRAF (R506_K507insVLR) Protein should be stored should be stored at < -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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