Recombinant Human Biglycan / BGN Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-0403
Recombinant Human Biglycan / BGN Protein (His Tag)
Beta LifeScience
SKU/CAT #: BLPSN-0403
Catalog No.: BLPSN-0403
Product Overview
| Tag | His |
| Host Species | Human |
| Accession | NP_001702.1 |
| Synonym | DSPG1, PG-S1, PGI, SLRR1A |
| Background | Biglycan, also known as PG-S1 and BGN, is a a small leucine-rich repeat proteoglycan (SLRP). It can be detected in a variety of extracellular matrix tissues, including bone, cartilage and tendon. Biglycan consists of a protein core containing leucine-rich repeat regions and two glycosaminoglycan (GAG) chains consisting of either chondroitin sulfate (CS) or dermatan sulfate (DS). Non-glycanated forms of biglycan (no GAG chains) increase with age in human articular cartilage. Biglycan interacts with collagen, both via the core protein and GAG chains. Biglycan plays a role in the mineralisation of bone. Biglycan core protein binds to the growth factors BMP-4 and influences its bioactivity. |
| Description | A DNA sequence encoding the human BGN (NP_001702.1) (Asp38-Lys368) was expressed with a His tag at the C-terminus. |
| Source | HEK293 |
| Predicted N Terminal | Asp 38 |
| AA Sequence | Asp38-Lys368 |
| Molecular Weight | The recombinant human BGN consists of 342 a.a. and predicts a molecular mass of 38.7 kDa. |
| Purity | >95% as determined by SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
| Bioactivity | Please contact us for detailed information |
| Formulation | Lyophilized from sterile PBS, pH 7.4.. |
| Stability | The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. |
| Usage | For Research Use Only |
| Storage | Store the protein under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
